Single versus multiple session stereotactic body radiotherapy for spinal metastasis: The risk-benefit ratio

Redmond, Kristin J., Sahgal, Arjun, Foote, Matthew, Knisely, Jonathan, Gerszten, Peter C., Chao, Samuel T., Suh, John H., Sloan, Andrew E., Chang, Eric L., Machtay, Mitchell and Lo, Simon S. (2015) Single versus multiple session stereotactic body radiotherapy for spinal metastasis: The risk-benefit ratio. Future Oncology, 11 17: 2405-2415. doi:10.2217/fon.15.160


Author Redmond, Kristin J.
Sahgal, Arjun
Foote, Matthew
Knisely, Jonathan
Gerszten, Peter C.
Chao, Samuel T.
Suh, John H.
Sloan, Andrew E.
Chang, Eric L.
Machtay, Mitchell
Lo, Simon S.
Title Single versus multiple session stereotactic body radiotherapy for spinal metastasis: The risk-benefit ratio
Journal name Future Oncology   Check publisher's open access policy
ISSN 1744-8301
1479-6694
Publication date 2015-09-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2217/fon.15.160
Open Access Status Not Open Access
Volume 11
Issue 17
Start page 2405
End page 2415
Total pages 11
Place of publication London, United Kingdom
Publisher Future Medicine
Collection year 2016
Language eng
Abstract Spine stereotactic body radiation therapy represents an important advancement in the management of spinal metastases that allows precise delivery of ablative doses of radiation therapy with excellent local control. Although the technique is being increasingly used in clinical practice, the optimal fractionation schedule remains uncertain. In this perspective paper, we review radiobiologic principles that support the use of multiple- versus single-fraction spine stereotactic body radiation therapy schedules and clinical data supporting the multiple-fraction approach. Specifically, we suggest that there may be a local control benefit of fractionation, while helping to limit the risk of toxicities such as vertebral body fracture, pain flare and radiation myelopathy. We conclude with future directions and the need for future study on this important topic.
Keyword hypofractionation
multiple-fraction spine treatment
spine stereotactic body radiation therapy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
 
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