Magnetic fields suppress Pseudomonas aeruginosa biofilms and enhance ciprofloxacin activity.

Bandara, H.M.H.N., Nguyen, D., Mogarala, S., Osinski, M. and Smyth, H.D.C. (2015) Magnetic fields suppress Pseudomonas aeruginosa biofilms and enhance ciprofloxacin activity.. Biofouling, 31 5: 443-457. doi:10.1080/08927014.2015.1055326.

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Author Bandara, H.M.H.N.
Nguyen, D.
Mogarala, S.
Osinski, M.
Smyth, H.D.C.
Title Magnetic fields suppress Pseudomonas aeruginosa biofilms and enhance ciprofloxacin activity.
Journal name Biofouling   Check publisher's open access policy
ISSN 1029-2454
0892-7014
Publication date 2015-06-23
Year available 2015
Sub-type Article (original research)
DOI 10.1080/08927014.2015.1055326.
Open Access Status Not Open Access
Volume 31
Issue 5
Start page 443
End page 457
Total pages 15
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Collection year 2016
Language eng
Formatted abstract
Due to the refractory nature of pathogenic microbial biofilms, innovative biofilm eradication strategies are constantly being sought. Thus, this study addresses a novel approach to eradicate Pseudomonas aeruginosa biofilms. Magnetic nanoparticles (MNP), ciprofloxacin (Cipro), and magnetic fields were systematically evaluated in vitro for their relative anti-biofilm contributions. Twenty-four-hour biofilms exposed to aerosolized MNPs, Cipro, or a combination of both, were assessed in the presence or absence of magnetic fields (Static one-sided, Static switched, Oscillating, Static + oscillating) using changes in bacterial metabolism, biofilm biomass, and biofilm imaging. The biofilms exposed to magnetic fields alone exhibited significant metabolic and biomass reductions (p < 0.05). When biofilms were treated with a MNP/Cipro combination, the most significant metabolic and biomass reductions were observed when exposed to static switched magnetic fields (p < 0.05). The exposure of P. aeruginosa biofilms to a static switched magnetic field alone, or co-administration with MNP/Cipro/MNP + Cipro appears to be a promising approach to eradicate biofilms of this bacterium.
Keyword Pseudomonas aeruginosa
Biofilms
Magnetic fields
Ciprofloxacin
Magnetic nanoparticles
Drug delivery
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Dentistry Publications
 
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Created: Wed, 14 Oct 2015, 15:14:43 EST by Nihal Bandara on behalf of School of Dentistry