Corticopontocerebellar connectivity disruption in congenital hemiplegia

Fiori, Simona, Pannek, Kerstin, Pasquariello, Rosa, Ware, Robert S., Cioni, Giovanni, Rose, Stephen E., Boyd, Roslyn N. and Guzzetta, Andrea (2015) Corticopontocerebellar connectivity disruption in congenital hemiplegia. Neurorehabilitation and Neural Repair, 29 9: 858-866. doi:10.1177/1545968314568726


Author Fiori, Simona
Pannek, Kerstin
Pasquariello, Rosa
Ware, Robert S.
Cioni, Giovanni
Rose, Stephen E.
Boyd, Roslyn N.
Guzzetta, Andrea
Title Corticopontocerebellar connectivity disruption in congenital hemiplegia
Journal name Neurorehabilitation and Neural Repair   Check publisher's open access policy
ISSN 1552-6844
1545-9683
Publication date 2015-10-29
Year available 2015
Sub-type Article (original research)
DOI 10.1177/1545968314568726
Open Access Status Not Open Access
Volume 29
Issue 9
Start page 858
End page 866
Total pages 9
Place of publication Thousand Oaks, California, United States
Publisher SAGE Publications
Collection year 2016
Language eng
Formatted abstract
Background. Crossed cerebellar diaschisis is the disruption of functional connectivity between cerebrum and cerebellum after hemispheric unilateral brain lesions. In adults and to a lesser extent in children, crossed cerebellar diaschisis has been largely investigated by functional connectivity and demonstrated to influence paretic hand function. Objective. We aim to demonstrate a disruption in structural corticopontocerebellar (CPC) connectivity in children with congenital brain lesions and examine its correlation with paretic hand motor function. Methods. Thirty-six children (Manual Ability Classification System: I, n = 21; II, n = 15) with unilateral brain lesions and 18 controls were analyzed in a case-control study, and diffusion magnetic resonance imaging data were acquired at 3T. High angular resolution diffusion imaging probabilistic tractography was employed for the region of interest–based reconstruction of CPC tracts. To identify statistical differences in structural cerebrocerebellar connectivity between case and control groups, an asymmetry index based on the number of streamlines of CPC tracts was used. In the case group, the correlation between asymmetry index and hand function measures was also determined. Results. Projections through the middle cerebellar peduncle to the contralateral cerebral cortex showed greater asymmetry in children with congenital unilateral brain lesion compared to controls (P = .03), thus indicating a disruption of structural cerebrocerebellar connectivity. The degree of asymmetry index showed a correlation (P < .03; r = −0.31) with impaired hand abilities in bimanual tasks. Conclusions. Disruption of structural cerebrocerebellar connectivity is present in patients with congenital unilateral brain injury and might be related to impaired hand function in bimanual skills, with potential implication in tailoring early intervention strategies.
Keyword cerebellum
crossed cerebellar diaschisis
congenital hemiplegia
cerebellum
cerebrocerebellar connectivity
hand function
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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