Hot flushes and night sweats are associated with coronary heart disease risk in midlife: A longitudinal study

Herber-Gast, G.C.M., Brown, W.J. and Mishra, G.D. (2015) Hot flushes and night sweats are associated with coronary heart disease risk in midlife: A longitudinal study. BJOG: An International Journal of Obstetrics and Gynaecology, 122 11: 1560-1567. doi:10.1111/1471-0528.13163

Author Herber-Gast, G.C.M.
Brown, W.J.
Mishra, G.D.
Title Hot flushes and night sweats are associated with coronary heart disease risk in midlife: A longitudinal study
Journal name BJOG: An International Journal of Obstetrics and Gynaecology   Check publisher's open access policy
ISSN 1471-0528
Publication date 2015-10-01
Year available 2015
Sub-type Article (original research)
DOI 10.1111/1471-0528.13163
Open Access Status Not Open Access
Volume 122
Issue 11
Start page 1560
End page 1567
Total pages 8
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2016
Language eng
Formatted abstract
Objective The purpose of this study was to investigate associations between vasomotor menopausal symptoms (VMS), i.e. hot flushes and night sweats, and the incidence of coronary heart disease (CHD).

Design A prospective cohort study.

Setting and population 11 725 women, aged 45–50 years at baseline in 1996, were followed up at 3-year intervals for 14 years.

Methods Self-reported VMS and incident CHD were measured at each survey.

Main outcome measure We determined the association between VMS and CHD at the subsequent survey, using generalised estimating equation analysis, adjusting for time-varying covariates.

Results At baseline, 14% reported rarely, 17% reported sometimes, and 7% reported often having night sweats. During follow-up, 187 CHD events occurred. In the age-adjusted analysis, women who reported their frequency of experiencing hot flushes and night sweats as ‘often’ had a greater than two-fold increased odds of CHD (OR hot flushes 2.18, 95% CI 1.49–3.18; OR night sweats 2.38, 95% CI 1.62–3.50) compared with women with no symptoms (P trend < 0.001 for frequency of symptoms). Adjustment for menopausal status, lifestyle factors, body mass index, diabetes, and hypertension attenuated the associations (OR hot flushes 1.70, 95% CI 1.16–2.51, P trend = 0.01; OR night sweats 1.84, 95% CI 1.24–2.73), P trend = 0.004).

Conclusions Women who report having hot flushes or night sweats ‘often’ have an increased risk of developing CHD over a period of 14 years, even after taking the effects of age, menopause status, lifestyle, and other chronic disease risk factors into account.
Keyword Coronary heart disease
longitudinal analyses
vasomotor menopausal symptoms
women's health
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Public Health Publications
School of Human Movement and Nutrition Sciences Publications
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