Myo-inositol metabolism in appropriately grown and growth-restricted fetuses: a proton magnetic resonance spectroscopy study

Story, Lisa, Damodaram, Mellisa S., Supramaniam, Veena, Allsop, Joanna M., Mcguinness, Amy, Patel, Abhilasha, Wylezinska, Marzena, Kumar, Sailesh and Rutherford, Mary A. (2013) Myo-inositol metabolism in appropriately grown and growth-restricted fetuses: a proton magnetic resonance spectroscopy study. European Journal of Obstetrics Gynecology and Reproductive Biology, 170 1: 77-81. doi:10.1016/j.ejogrb.2013.05.006


Author Story, Lisa
Damodaram, Mellisa S.
Supramaniam, Veena
Allsop, Joanna M.
Mcguinness, Amy
Patel, Abhilasha
Wylezinska, Marzena
Kumar, Sailesh
Rutherford, Mary A.
Title Myo-inositol metabolism in appropriately grown and growth-restricted fetuses: a proton magnetic resonance spectroscopy study
Journal name European Journal of Obstetrics Gynecology and Reproductive Biology   Check publisher's open access policy
ISSN 0301-2115
1872-7654
Publication date 2013-09-01
Sub-type Article (original research)
DOI 10.1016/j.ejogrb.2013.05.006
Open Access Status Not Open Access
Volume 170
Issue 1
Start page 77
End page 81
Total pages 5
Place of publication E Park, Shannon, Clare Ireland
Publisher Elsevier Ireland
Language eng
Formatted abstract
Objective

Myo-inositol (Myo-ins) is a marker of neuroglial cells, being present in the astrocytes of brain tissue, but also functions as an osmolyte. Numbers of astrocytes are known to increase following injury to the brain. Growth-restricted fetuses are at increased risk of later neurodevelopmental impairments even in the absence of overt lesions and despite preserved/increased cerebral blood flow. This study aims to investigate brain Myo-ins metabolism in fetuses with intrauterine growth restriction (IUGR) and evidence of cerebral redistribution using magnetic resonance spectroscopy (MRS) at a short echo time.

Study design

Biometry and Doppler assessment of blood flow was assessed using ultrasound in 28 fetuses with IUGR and 47 appropriately grown control subjects. MRI was used to exclude overt brain injury. Proton magnetic resonance spectroscopy of the fetal brain was then performed at an echo time of 42 ms to examine the Myo-ins:Choline (Cho), Myo-ins:Creatine (Cr) and Cho:Cr ratios.

Results

No alterations in brain Myo-ins:Cho, Myo-ins:Cr or Cho:Cr ratios were detected between appropriately grown and growth restricted fetuses.

Conclusions

IUGR is not associated with a measureable difference in brain myo-inositol ratios. This may be due to the protective effects of preserved cerebral blood flow in growth restriction and comparable astrocyte numbers when compared to controls.
Keyword Fetal growth restriction
Brain
Magnetic resonance spectroscopy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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