Psychophysiological phenotypes of cognition: The P3 and SW components

Wright, M. J., Hansell, N., Geffen, G. M., Geffen, L., Smith, G. and Martin, N. (2000). Psychophysiological phenotypes of cognition: The P3 and SW components. In: Behavior Genetics: Behavior Genetics Association Meeting Abstracts. 30th Annual Meeting of the Behavior Genetics Association, Burlington, Vermont, USA, (422-422). June 29 - July 1, 2000. doi:10.1023/A:1017371222025

Author Wright, M. J.
Hansell, N.
Geffen, G. M.
Geffen, L.
Smith, G.
Martin, N.
Title of paper Psychophysiological phenotypes of cognition: The P3 and SW components
Conference name 30th Annual Meeting of the Behavior Genetics Association
Conference location Burlington, Vermont, USA
Conference dates June 29 - July 1, 2000
Proceedings title Behavior Genetics: Behavior Genetics Association Meeting Abstracts   Check publisher's open access policy
Journal name Behavior Genetics   Check publisher's open access policy
Place of Publication Westport, United States
Publisher Kluwer
Publication Year 2000
Sub-type Published abstract
DOI 10.1023/A:1017371222025
ISSN 0001-8244
Volume 30
Issue 5
Start page 422
End page 422
Total pages 1
Language eng
Abstract/Summary As part of a large ongoing project, the Memory, Attention and Problem Solving (MAPS) study, we investigated whether genetic variability explains some of the variance in psychophysiological correlates of brain function, namely, the P3 and SW components of event-related potentials (ERPs). These ERP measures are minute time recordings of brain processes and, because they reflect fundamental cognitive processing, provide a unique window on the millisecondto- millisecond transactions that occur at the cognitive level and taking place in the human brain. The extent to which the variance in P3 and SW components is influenced by genetic factors was examined in 350 identical and nonidentical twin pairs aged 16 years. ERPs were recorded from 15 scalp electrodes during the performance of a visuospatial delayed response task that engages working memory. Multivariate genetic analyses using MX were used to estimate genetic and environmental influences on individual differences in brain functioning and to identify putative genetic factors common to the ERP measures and psychometric IQ. For each of the ERP measures, correlation among electrode sites was high, a spatial pattern was evident, and a large part of the genetic variation in the ERPs appeared to be mediated by a common genetic factor. Moderate within-pair concordance in MZ pairs was found for all ERP measures, with higher correlations found for P3 than SW, and the MZ twin pair correlations were approximately twice the DZ correlations, suggesting a genetic influence. Correlations between ERP measures and psychometric IQ were found and, although moderately low, were evident across electrode site. The analyses show that the ERP components, P3 and SW, are promising phenotypes of the neuroelectrical activity of the brain and have the potential to be used in linkage and association analysis in the search for QTLs influencing cognitive function.
Subjects 1701 Psychology
Keyword Behavioral Sciences
Genetics & Heredity
Psychology, Multidisciplinary
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Collections: School of Medicine Publications
School of Psychology Publications
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Created: Mon, 13 Aug 2007, 12:12:52 EST