Expression of myostatin in intrauterine growth restriction and preeclampsia complicated pregnancies and alterations to cytokine production by first-trimester placental explants following myostatin treatment

Peiris, Hassendrini N., Georgiou, Harry, Lappas, Martha, Kaitu'U-Lino, Tu’uhevaha, Salomon, Carlos, Vaswani, Kanchan, Rice, Gregory E. and Mitchell, Murray D. (2015) Expression of myostatin in intrauterine growth restriction and preeclampsia complicated pregnancies and alterations to cytokine production by first-trimester placental explants following myostatin treatment. Reproductive Sciences, 22 10: 1202-1211. doi:10.1177/1933719115572482


Author Peiris, Hassendrini N.
Georgiou, Harry
Lappas, Martha
Kaitu'U-Lino, Tu’uhevaha
Salomon, Carlos
Vaswani, Kanchan
Rice, Gregory E.
Mitchell, Murray D.
Title Expression of myostatin in intrauterine growth restriction and preeclampsia complicated pregnancies and alterations to cytokine production by first-trimester placental explants following myostatin treatment
Journal name Reproductive Sciences   Check publisher's open access policy
ISSN 1933-7191
1933-7205
Publication date 2015-10-22
Sub-type Article (original research)
DOI 10.1177/1933719115572482
Open Access Status DOI
Volume 22
Issue 10
Start page 1202
End page 1211
Total pages 10
Place of publication Thousand Oaks, CA United States
Publisher Sage Publications
Collection year 2016
Language eng
Formatted abstract
Preeclampsia (PE) and intrauterine growth restriction (IUGR) are major obstetric health problems. Higher levels of T-helper (Th) 1 (proinflammatory) cytokines have been observed in pregnancies complicated with PE and IUGR; this is in contrast to the predominant Th2 (anti-inflammatory) cytokine environment found in uncomplicated pregnancies. Myostatin is best known as a negative regulator of muscle development and reportedly has a role in fat deposition, glucose metabolism, and cytokine modulation (outside the placenta). Myostatin concentrations in plasma and protein expression in placental tissue are significantly higher in women with PE. Expression of myostatin in IUGR and PE-IUGR and the effect of this protein on the cytokine production from the placenta is unknown. In the current study, significant differences were identified in the expression of myostatin in pregnancies complicated with IUGR, PE, and PE with IUGR. Furthermore, cytokine production by first-trimester placental tissues was altered following myostatin treatment.
Keyword Growth Differentiation Factor 8 (GDF 8)
Intrauterine growth restriction
Myostatin
Placenta
Preeclampsia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
 
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