Gene expression data from the moon jelly, Aurelia, provide insights into the evolution of the combinatorial code controlling animal sense organ development

Nakanishi, Nagayasu, Camara, Anthony C., Yuan, David C., Gold, David A. and Jacobs, David K. (2015) Gene expression data from the moon jelly, Aurelia, provide insights into the evolution of the combinatorial code controlling animal sense organ development. PLoS ONE, 10 7: . doi:10.1371/journal.pone.0132544


Author Nakanishi, Nagayasu
Camara, Anthony C.
Yuan, David C.
Gold, David A.
Jacobs, David K.
Title Gene expression data from the moon jelly, Aurelia, provide insights into the evolution of the combinatorial code controlling animal sense organ development
Journal name PLoS ONE   Check publisher's open access policy
ISSN 1932-6203
Publication date 2015-07-30
Year available 2015
Sub-type Article (original research)
DOI 10.1371/journal.pone.0132544
Open Access Status DOI
Volume 10
Issue 7
Total pages 19
Place of publication San Francisco, California, United States
Publisher Public Library of Science
Collection year 2016
Language eng
Formatted abstract
In Bilateria, Pax6, Six, Eya and Dach families of transcription factors underlie the development and evolution of morphologically and phyletically distinct eyes, including the compound eyes in Drosophila and the camera-type eyes in vertebrates, indicating that bilaterian eyes evolved under the strong influence of ancestral developmental gene regulation. However the conservation in eye developmental genetics deeper in the Eumetazoa, and the origin of the conserved gene regulatory apparatus controlling eye development remain unclear due to limited comparative developmental data from Cnidaria. Here we show in the eye-bearing scyphozoan cnidarian Aurelia that the ectodermal photosensory domain of the developing medusa sensory structure known as the rhopalium expresses sine oculis (so)/six1/2 and eyes absent/eya, but not optix/six3/6 or pax (A&B). In addition, the so and eya co-expression domain encompasses the region of active cell proliferation, neurogenesis, and mechanoreceptor development in rhopalia. Consistent with the role of so and eya in rhopalial development, developmental transcriptome data across Aurelia life cycle stages show upregulation of so and eya, but not optix or pax (A&B), during medusa formation. Moreover, pax6 and dach are absent in the Aurelia genome, and thus are not required for eye development in Aurelia. Our data are consistent with so and eya, but not optix, pax or dach, having conserved functions in sensory structure specification across Eumetazoa. The lability of developmental components including Pax genes relative to so-eya is consistent with a model of sense organ development and evolution that involved the lineage specific modification of a combinatorial code that specifies animal sense organs.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Biological Sciences Publications
 
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