The Murray collection of pre-antibiotic era Enterobacteriacae: A unique research resource

Baker, Kate S., Burnett, Edward, McGregor, Hannah, Deheer-Graham, Ana, Boinett, Christine, Langridge, Gemma C., Wailan, Alexander M., Cain, Amy K., Thomson, Nicholas R., Russell, Julie E. and Parkhill, Julian (2015) The Murray collection of pre-antibiotic era Enterobacteriacae: A unique research resource. Genome Medicine, 7 97: . doi:10.1186/s13073-015-0222-7


Author Baker, Kate S.
Burnett, Edward
McGregor, Hannah
Deheer-Graham, Ana
Boinett, Christine
Langridge, Gemma C.
Wailan, Alexander M.
Cain, Amy K.
Thomson, Nicholas R.
Russell, Julie E.
Parkhill, Julian
Title The Murray collection of pre-antibiotic era Enterobacteriacae: A unique research resource
Journal name Genome Medicine   Check publisher's open access policy
ISSN 1756-994X
Publication date 2015-09-28
Year available 2015
Sub-type Article (original research)
DOI 10.1186/s13073-015-0222-7
Open Access Status Not Open Access
Volume 7
Issue 97
Total pages 7
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2016
Language eng
Abstract Studies of historical isolates inform on the evolution and emergence of important pathogens and phenotypes, including antimicrobial resistance. Crucial to studying antimicrobial resistance are isolates that predate the widespread clinical use of antimicrobials. The Murray collection of several hundred bacterial strains of pre-antibiotic era Enterobacteriaceae is an invaluable resource of historical strains from important pathogen groups. Studies performed on the Collection to date merely exemplify its potential, which will only be realised through the continued effort of many scientific groups. To enable that aim, we announce the public availability of the Murray collection through the National Collection of Type Cultures, and present associated metadata with whole genome sequence data for over half of the strains. Using this information we verify the metadata for the collection with regard to subgroup designations, equivalence groupings and plasmid content. We also present genomic analyses of population structure and determinants of mobilisable antimicrobial resistance to aid strain selection in future studies. This represents an invaluable public resource for the study of these important pathogen groups and the emergence and evolution of antimicrobial resistance.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
 
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