Quality of life (QoL) and International Normalized Ratio (INR) control of patients attending anticoagulation clinics

Hasan, S. S., Teh, K. M., Ahmed, S. I., Chong, D. W. K., Ong, H. C. and Naina, B. (2015) Quality of life (QoL) and International Normalized Ratio (INR) control of patients attending anticoagulation clinics. Public Health, 129 7: 954-962. doi:10.1016/j.puhe.2015.05.014

Author Hasan, S. S.
Teh, K. M.
Ahmed, S. I.
Chong, D. W. K.
Ong, H. C.
Naina, B.
Title Quality of life (QoL) and International Normalized Ratio (INR) control of patients attending anticoagulation clinics
Journal name Public Health   Check publisher's open access policy
ISSN 1476-5616
Publication date 2015-07-01
Sub-type Article (original research)
DOI 10.1016/j.puhe.2015.05.014
Open Access Status Not Open Access
Volume 129
Issue 7
Start page 954
End page 962
Total pages 9
Place of publication London, United Kingdom
Publisher W.B. Saunders
Collection year 2016
Language eng
Formatted abstract
Objectives: To investigate association between quality of life (QoL) and International Normalized Ratio (INR) control, with the secondary aim of assessing QoL using generic and anticoagulation-specific, the Short Form Health Survey (SF-12) and the Duke Anticoagulation Satisfaction Scale (DASS).

Study design: This study assessed anticoagulation related QoL at three time intervals in two groups of patients on long-term warfarin therapy.

Methods: Data of 326 randomly sampled patients (163 patients each in DASS and SF-12 groups) who had been on warfarin therapy for at least one year at anticoagulation clinics were analysed. QoL was assessed at three time intervals: at the start, six months and one year of warfarin therapy. Indications and target INR ranges and subjects INR values were recorded. Time in Therapeutic Range (TTR) was estimated for four subject subgroups, based on target ranges of INR for clustered indications.

Results: Of the total, 43% of the subjects were aged between 50 and 64 years, and 51% were female. DASS assessed subjects older than 35 years perceived significant decrease in overall mean scores of anticoagulation related QoL, whilst all SF-12 assessed subjects perceived an increase in QoL. The mean percentage days in range for all INR target range subgroups did not exceed more than 60% but there was only a weak correlation (Rs = 0.104, P > 0.05) between INR control and overall QoL.

Conclusion: Malaysian urban outpatients on warfarin treatment longer than one year report a significant overall decrease in QoL, as measured using a validated condition-specific instrument. These patients appeared to adapt well to lifestyle limitations imposed by long-term anticoagulation.
Keyword Anticoagulation therapy
International normalized ratio
Quality of life
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Pharmacy Publications
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