Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

Law, Matthew H., Bishop, D. Timothy, Lee, Jeffrey E., Brossard, Myriam, Martin, Nicholas G., Moses, Eric K., Song, Fengju, Barrett, Jennifer H., Kumar, Rajiv, Easton, Douglas F., Pharoah, Paul D. P., Swerdlow, Anthony J., Kypreou, Katerina P., Taylor, John C., Harland, Mark, Randerson-Moor, Juliette, Akslen, Lars A., Andresen, Per A., Avril, Marie-Franoise, Azizi, Esther, Scarra, Giovanna Bianchi, Brown, Kevin M., Debniak, Tadeusz, Duffy, David L., Elder, David E., Fang, Shenying, Friedman, Eitan, Galan, Pilar, Ghiorzo, Paola, Gillanders, Elizabeth M., Goldstein, Alisa M., Gruis, Nelleke A., Hansson, Johan, Helsing, Per, Hocevar, Marko, Hoeiom, Veronica, Ingvar, Christian, Kanetsky, Peter A., Chen, Wei V., Landi, Maria Teresa, Lang, Julie, Lathrop, G. Mark, Lubinski, Jan, Mackie, Rona M., Mann, Graham J., Molven, Anders, Montgomery, Grant W., Novakovic, Srdjan, Olsson, Hakan, Puig, Susana, Puig-Butille, Joan Anton, Qureshi, Abrar A., Radford-Smith, Graham L., van der Stoep, Nienke, van Doorn, Remco, Whiteman, David C., Craig, Jamie E., Schadendorf, Dirk, Simms, Lisa A., Burdon, Kathryn P., Nyholt, Dale R., Pooley, Karen A., Orr, Nick, Stratigos, Alexander J., Cust, Anne E., Ward, Sarah V., Hayward, Nicholas K., Han, Jiali, Schulze, Hans-Joachim, Dunning, Alison M., Bishop, Julia A. Newton, Demenais, Florence, Amos, Christopher I., MacGregor, Stuart and Iles, Mark M. (2015) Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nature Genetics, 47 9: 987-995. doi:10.1038/ng.3373


Author Law, Matthew H.
Bishop, D. Timothy
Lee, Jeffrey E.
Brossard, Myriam
Martin, Nicholas G.
Moses, Eric K.
Song, Fengju
Barrett, Jennifer H.
Kumar, Rajiv
Easton, Douglas F.
Pharoah, Paul D. P.
Swerdlow, Anthony J.
Kypreou, Katerina P.
Taylor, John C.
Harland, Mark
Randerson-Moor, Juliette
Akslen, Lars A.
Andresen, Per A.
Avril, Marie-Franoise
Azizi, Esther
Scarra, Giovanna Bianchi
Brown, Kevin M.
Debniak, Tadeusz
Duffy, David L.
Elder, David E.
Fang, Shenying
Friedman, Eitan
Galan, Pilar
Ghiorzo, Paola
Gillanders, Elizabeth M.
Goldstein, Alisa M.
Gruis, Nelleke A.
Hansson, Johan
Helsing, Per
Hocevar, Marko
Hoeiom, Veronica
Ingvar, Christian
Kanetsky, Peter A.
Chen, Wei V.
Landi, Maria Teresa
Lang, Julie
Lathrop, G. Mark
Lubinski, Jan
Mackie, Rona M.
Mann, Graham J.
Molven, Anders
Montgomery, Grant W.
Novakovic, Srdjan
Olsson, Hakan
Puig, Susana
Puig-Butille, Joan Anton
Qureshi, Abrar A.
Radford-Smith, Graham L.
van der Stoep, Nienke
van Doorn, Remco
Whiteman, David C.
Craig, Jamie E.
Schadendorf, Dirk
Simms, Lisa A.
Burdon, Kathryn P.
Nyholt, Dale R.
Pooley, Karen A.
Orr, Nick
Stratigos, Alexander J.
Cust, Anne E.
Ward, Sarah V.
Hayward, Nicholas K.
Han, Jiali
Schulze, Hans-Joachim
Dunning, Alison M.
Bishop, Julia A. Newton
Demenais, Florence
Amos, Christopher I.
MacGregor, Stuart
Iles, Mark M.
Title Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1546-1718
1061-4036
Publication date 2015-09-01
Year available 2015
Sub-type Article (original research)
DOI 10.1038/ng.3373
Open Access Status Not Open Access
Volume 47
Issue 9
Start page 987
End page 995
Total pages 9
Place of publication New York, United States
Publisher Nature Publishing Group
Collection year 2016
Language eng
Formatted abstract
Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10−8), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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