Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium

Nagle, C. M., Dixon, S. C., Jensen, A., Kjaer, S. K., Modugno, F., deFazio, A., Fereday, S., Hung, J., Johnatty, S. E., Fasching, P. A., Beckmann, M. W., Lambrechts, D., Vergote, I., Van Nieuwenhuysen, E., Lambrechts, S., Risch, H. A., Rossing, M. A., Doherty, J. A., Wicklund, K. G., Chang-Claude, J., Goodman, M. T., Ness, R. B., Moysich, K., Heitz, F., du Bois, A., Harter, P., Schwaab, I., Matsuo, K., Hosono, S., Goode, E. L., Vierkant, R. A., Larson, M. C., Fridley, B. L., Hogdall, C., Schildkraut, J. M., Weber, R. P., Cramer, D. W., Terry, K. L., Bandera, E. V., Paddock, L., Rodriguez-Rodriguez, L., Wentzensen, N., Yang, H. P., Brinton, L. A., Lissowska, J., Hogdall, E., Lundvall, L., Whittemore, A., McGuire, V., Sieh, W., Rothstein, J., Sutphen, R., Anton-Culver, H., Ziogas, A., Pearce, C. L., Wu, A. H., Webb, P. M. and Ovarian Cancer Association Consortium (2015) Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium. British Journal of Cancer, 113 5: 817-826. doi:10.1038/bjc.2015.245


Author Nagle, C. M.
Dixon, S. C.
Jensen, A.
Kjaer, S. K.
Modugno, F.
deFazio, A.
Fereday, S.
Hung, J.
Johnatty, S. E.
Fasching, P. A.
Beckmann, M. W.
Lambrechts, D.
Vergote, I.
Van Nieuwenhuysen, E.
Lambrechts, S.
Risch, H. A.
Rossing, M. A.
Doherty, J. A.
Wicklund, K. G.
Chang-Claude, J.
Goodman, M. T.
Ness, R. B.
Moysich, K.
Heitz, F.
du Bois, A.
Harter, P.
Schwaab, I.
Matsuo, K.
Hosono, S.
Goode, E. L.
Vierkant, R. A.
Larson, M. C.
Fridley, B. L.
Hogdall, C.
Schildkraut, J. M.
Weber, R. P.
Cramer, D. W.
Terry, K. L.
Bandera, E. V.
Paddock, L.
Rodriguez-Rodriguez, L.
Wentzensen, N.
Yang, H. P.
Brinton, L. A.
Lissowska, J.
Hogdall, E.
Lundvall, L.
Whittemore, A.
McGuire, V.
Sieh, W.
Rothstein, J.
Sutphen, R.
Anton-Culver, H.
Ziogas, A.
Pearce, C. L.
Wu, A. H.
Webb, P. M.
Ovarian Cancer Association Consortium
Title Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 0007-0920
1532-1827
Publication date 2015-09
Sub-type Article (original research)
DOI 10.1038/bjc.2015.245
Open Access Status Not Open Access
Volume 113
Issue 5
Start page 817
End page 826
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2016
Language eng
Formatted abstract
Background: Observational studies have reported a modest association between obesity and risk of ovarian cancer; however, whether it is also associated with survival and whether this association varies for the different histologic subtypes are not clear. We undertook an international collaborative analysis to assess the association between body mass index (BMI), assessed shortly before diagnosis, progression-free survival (PFS), ovarian cancer-specific survival and overall survival (OS) among women with invasive ovarian cancer.

Methods: We used original data from 21 studies, which included 12 390 women with ovarian carcinoma. We combined study-specific adjusted hazard ratios (HRs) using random-effects models to estimate pooled HRs (pHR). We further explored associations by histologic subtype.

Results: Overall, 6715 (54%) deaths occurred during follow-up. A significant OS disadvantage was observed for women who were obese (BMI: 30–34.9, pHR: 1.10 (95% confidence intervals (CIs): 0.99–1.23); BMI: greater than or equal to35, pHR: 1.12 (95% CI: 1.01–1.25)). Results were similar for PFS and ovarian cancer-specific survival. In analyses stratified by histologic subtype, associations were strongest for women with low-grade serous (pHR: 1.12 per 5 kg m−2) and endometrioid subtypes (pHR: 1.08 per 5 kg m−2), and more modest for the high-grade serous (pHR: 1.04 per 5 kg m−2) subtype, but only the association with high-grade serous cancers was significant.

Conclusions: Higher BMI is associated with adverse survival among the majority of women with ovarian cancer.
Keyword Ovarian cancer
Obesity
Overall survival
Progression-free survival
Ovarian cancer-specific survival
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Public Health Publications
 
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