Does pregnancy per se make epilepsy worse?

Vajda, F.J.E., O'Brien, T.J., Lander, C.M., Graham, J. and Eadie, M.J. (2015) Does pregnancy per se make epilepsy worse?. Acta Neurologica Scandinavica, 133 5: 380-383. doi:10.1111/ane.12479


Author Vajda, F.J.E.
O'Brien, T.J.
Lander, C.M.
Graham, J.
Eadie, M.J.
Title Does pregnancy per se make epilepsy worse?
Journal name Acta Neurologica Scandinavica   Check publisher's open access policy
ISSN 1600-0404
0001-6314
Publication date 2015-09-08
Year available 2015
Sub-type Article (original research)
DOI 10.1111/ane.12479
Open Access Status Not Open Access
Volume 133
Issue 5
Start page 380
End page 383
Total pages 4
Place of publication Malden, Massachusetts, United States
Publisher Wiley-Blackwell Publishing
Collection year 2016
Language eng
Formatted abstract
Objective
To determine whether being pregnant in its own right alters epileptic seizure control.

Materials/Methods
Study of 148 pregnancies in women who took no antiepileptic drugs before pregnancy and in at least the earlier half of pregnancy, 69 taking none throughout pregnancy.

Results
More women (P < 0.01) had seizures of any type during pregnancy (45.9%) than in the prepregnancy year (34.5%), and also convulsive seizures (30.4% vs 12.3%). After excluding potential confounding factors, viz. late prepregnancy drug withdrawal, treatment resumption in pregnancy possibly preventing seizure recurrence, the figures became seizures of any type 56.6% during and 35.5% before pregnancy and convulsive seizures 39.4% during and 18.2% before pregnancy (both P < 0.01). There was a non-statistically significant greater tendency for seizure control to be lost during pregnancy in genetic generalized than in focal epilepsies (54.2% vs 35.5%).

Conclusions
Irrespective of its effects on antiepileptic drug disposition, being pregnant per se seems to impair epileptic seizure control.
Keyword Antiepileptic drugs
Epilepsy
Pregnancy
Seizure control
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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