Population genetic differentiation of height and body mass index across Europe

Robinson, Matthew R., Hemani, Gibran, Medina-Gomez, Carolina, Mezzavilla, Massimo, Esko, Tonu, Shakhbazov, Konstantin, Powell, Joseph E., Vinkhuyzen, Anna, Berndt, Sonja I., Gustafsson, Stefan, Justice, Anne E., Kahali, Bratati, Locke, Adam E., Pers, Tune H., Vedantam, Sailaja, Wood, Andrew R., van Rheenen, Wouter, Andreassen, Ole A., Gasparini, Paolo, Metspalu, Andres, van den Berg, Leonard H., Veldink, Jan H., Rivadeneira, Fernando, Werge, Thomas M., Abecasis, Goncalo R., Boomsma, Dorret I., Chasman, Daniel I., de Geus, Eco J. C., Frayling, Timothy M., Hirschhorn, Joel N., Hottenga, Jouke Jan, Ingelsson, Erik, Loos, Ruth J. F., Magnusson, Patrik K. E., Martin, Nicholas G., Montgomery, Grant W., North, Kari E., Pedersen, Nancy L., Spector, Timothy D., Speliotes, Elizabeth K., Goddard, Michael E., Yang, Jian and Visscher, Peter M. (2015) Population genetic differentiation of height and body mass index across Europe. Nature Genetics, 47 11: 1357-1361. doi:10.1038/ng.3401

Author Robinson, Matthew R.
Hemani, Gibran
Medina-Gomez, Carolina
Mezzavilla, Massimo
Esko, Tonu
Shakhbazov, Konstantin
Powell, Joseph E.
Vinkhuyzen, Anna
Berndt, Sonja I.
Gustafsson, Stefan
Justice, Anne E.
Kahali, Bratati
Locke, Adam E.
Pers, Tune H.
Vedantam, Sailaja
Wood, Andrew R.
van Rheenen, Wouter
Andreassen, Ole A.
Gasparini, Paolo
Metspalu, Andres
van den Berg, Leonard H.
Veldink, Jan H.
Rivadeneira, Fernando
Werge, Thomas M.
Abecasis, Goncalo R.
Boomsma, Dorret I.
Chasman, Daniel I.
de Geus, Eco J. C.
Frayling, Timothy M.
Hirschhorn, Joel N.
Hottenga, Jouke Jan
Ingelsson, Erik
Loos, Ruth J. F.
Magnusson, Patrik K. E.
Martin, Nicholas G.
Montgomery, Grant W.
North, Kari E.
Pedersen, Nancy L.
Spector, Timothy D.
Speliotes, Elizabeth K.
Goddard, Michael E.
Yang, Jian
Visscher, Peter M.
Title Population genetic differentiation of height and body mass index across Europe
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1546-1718
Publication date 2015-09-14
Sub-type Article (original research)
DOI 10.1038/ng.3401
Open Access Status Not Open Access
Volume 47
Issue 11
Start page 1357
End page 1361
Total pages 8
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Collection year 2016
Language eng
Formatted abstract
Across-nation differences in the mean values for complex traits are common1, 2, 3, 4, 5, 6, 7, 8, but the reasons for these differences are unknown. Here we find that many independent loci contribute to population genetic differences in height and body mass index (BMI) in 9,416 individuals across 14 European countries. Using discovery data on over 250,000 individuals and unbiased effect size estimates from 17,500 sibling pairs, we estimate that 24% (95% credible interval (CI) = 9%, 41%) and 8% (95% CI = 4%, 16%) of the captured additive genetic variance for height and BMI, respectively, reflect population genetic differences. Population genetic divergence differed significantly from that in a null model (height, P < 3.94 × 10−8; BMI, P < 5.95 × 10−4), and we find an among-population genetic correlation for tall and slender individuals (r = −0.80, 95% CI = −0.95, −0.60), consistent with correlated selection for both phenotypes. Observed differences in height among populations reflected the predicted genetic means (= 0.51; P < 0.001), but environmental differences across Europe masked genetic differentiation for BMI (P < 0.58).
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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