Average wild-type C57BL/6J mouse 3D MRI Basal Ganglia labels

Egan, Gary F., Reutens, David, Galloway, Graham J., Watson, Charles, Andrew Janke, Kurniawan, Nyoman D. and Ullmann, Jeremy F. (2015): Average wild-type C57BL/6J mouse 3D MRI Basal Ganglia labels. The University of Queensland. Dataset. doi:10.14264/uql.2015.867

Project name Australian Mouse Brain Mapping
Project description
We propose to establish the Australian Mouse Brain Mapping Consortium which is a national network of facilities allowing Australian researchers to better characterise mouse models of neurological diseases such as Alzheimer's Disease and stroke. Just as accurate maps were key to the voyages of geographic discovery in the 17th and 18th century, improved methods of mapping structural and functional changes in the brain of mouse models of neurological disease will be key to discovery in the neurosciences in the 21st century . For the Consortium the cartographic tools will be magnetic resonance imaging (MRI), microscopy and sophisticated computational methods of mapping brain structure and function. Participants in the Consortium are internationally recognised leaders in brain imaging based at Monash University, the Howard Florey Institute, the Prince of Wales Medical Research Institute and the Centre for Magnetic Resonance and the Queensland Brain Institute, University of Queensland.
Contact name Andrew Janke
Contact email andrew.janke@cai.uq.edu.au
Creator name Egan, Gary F.
Reutens, David
Galloway, Graham J.
Watson, Charles
Andrew Janke
Kurniawan, Nyoman D.
Ullmann, Jeremy F.
Creator(s) role Senior Researcher
Senior Researcher
Senior Researcher
Senior Researcher
Senior Researcher
Senior Researcher
Senior Researcher
Dataset name Average wild-type C57BL/6J mouse 3D MRI Basal Ganglia labels
Dataset description
The basal ganglia are group of subpallial nuclei that play an important role inmotor, emotional, and cognitive functions. Morphological changes and disrupted afferent/efferent connections in the basal ganglia have been associated with a variety of neurological disorders including psychiatric and movement disorders. While high-resolution magnetic resonance imaging has been used to characterize changes in brain structure in mouse models of these disorders no systematicmethod for segmentation of the C57BL/6J mouse basal ganglia exists. In this study we have used high-resolution MR images of ex-vivo C57BL/6J mouse brain to create a detailed protocol for segmenting the basal ganglia. We created a three-dimensional minimum deformation atlas, which includes the segmentation of 35 striatal, pallidal, and basal ganglia-related structures. In addition, we provide mean volumes, mean T2 contrast intensities and mean FA and ADC values for each structure. This MR atlas is available for download, and enables researchers to perform automated segmentation in genetic models of basal ganglia disorders.
Access conditions Open Access
Licencing and terms of access Creative Commons Attribution (only)

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ANZSRC Field of Research (FoR) Code 060805 Animal Neurobiology
1109 Neurosciences
110903 Central Nervous System
DOI 10.14264/uql.2015.867
Grant ID http://purl.org/au-research/grants/nhmrc/436673
Type of data MRI images
Language eng
Keyword Mouse brain mapping
Basal Ganglia
Magnetic Resonance Imaging
Collection type Dataset
Publisher The University of Queensland
Publication Year 2015
Copyright notice 2015, The University of Queensland
Additional Notes whole data collection location: http://q0013-webdav.qcloud.qcif.edu.au/desktop.html?ds=5&plane=y&x=-2.196&y=-0.576&z=-3.665&zoom=3

Document type: Data Collection
Collections: Research Data Collections
Centre for Advanced Imaging Publications
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Created: Fri, 25 Sep 2015, 12:06:30 EST by Fei Yu