Excess mortality from mental, neurological and substance use disorders in the Global Burden of Disease Study 2010

Charlson, Fiona J., Baxter, Amanda J., Dua, T., Degenhardt, Louisa, Whiteford, Harvey A. and Vos, Theo (2015) Excess mortality from mental, neurological and substance use disorders in the Global Burden of Disease Study 2010. Epidemiology and Psychiatric Sciences, 24 2: 121-140. doi:10.1017/S2045796014000687


Author Charlson, Fiona J.
Baxter, Amanda J.
Dua, T.
Degenhardt, Louisa
Whiteford, Harvey A.
Vos, Theo
Title Excess mortality from mental, neurological and substance use disorders in the Global Burden of Disease Study 2010
Journal name Epidemiology and Psychiatric Sciences   Check publisher's open access policy
ISSN 2045-7960
2045-7979
Publication date 2015-04-01
Year available 2014
Sub-type Article (original research)
DOI 10.1017/S2045796014000687
Open Access Status DOI
Volume 24
Issue 2
Start page 121
End page 140
Total pages 20
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2016
Language eng
Formatted abstract
Aims: Mortality-associated burden of disease estimates from the Global Burden of Disease 2010 (GBD 2010) may erroneously lead to the interpretation that premature death in people with mental, neurological and substance use disorders (MNSDs) is inconsequential when evidence shows that people with MNSDs experience a significant reduction in life expectancy. We explore differences between cause-specific and excess mortality of MNSDs estimated by GBD 2010.

Methods: GBD 2010 cause-specific death estimates were produced using the International Classification of Diseases death-coding system. Excess mortality (all-cause) was estimated using natural history models. Additional mortality attributed to MNSDs as underlying causes but not captured through GBD 2010 methodology is quantified in the comparative risk assessments.

Results: In GBD 2010, MNSDs were estimated to be directly responsible for 840 000 deaths compared with more than 13 million excess deaths using natural history models.

Conclusions: Numbers of excess deaths and attributable deaths clearly demonstrate the high degree of mortality associated with these disorders. There is substantial evidence pointing to potential causal pathways for this premature mortality with evidence-based interventions available to address this mortality. The life expectancy gap between persons with MNSDs and the general population is high and should be a focus for health systems reform.
Keyword Global burden of disease
Mental health
Mortality
Neuropsychiatry
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Public Health Publications
 
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Created: Wed, 23 Sep 2015, 01:57:00 EST by Amanda Baxter on behalf of School of Public Health