Bisphenol A exposure pathways in early childhood: reviewing the need for improved risk assessment models

Healy, Bridget F., English, Karin R., Jagals, Paul and Sly, Peter D. (2015) Bisphenol A exposure pathways in early childhood: reviewing the need for improved risk assessment models. Journal of Exposure Science and Environmental Epidemiology, 25 6: 544-556. doi:10.1038/jes.2015.49


Author Healy, Bridget F.
English, Karin R.
Jagals, Paul
Sly, Peter D.
Title Bisphenol A exposure pathways in early childhood: reviewing the need for improved risk assessment models
Journal name Journal of Exposure Science and Environmental Epidemiology   Check publisher's open access policy
ISSN 1559-0631
1559-064X
Publication date 2015-09-09
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/jes.2015.49
Open Access Status Not Open Access
Volume 25
Issue 6
Start page 544
End page 556
Total pages 13
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2016
Language eng
Formatted abstract
Bisphenol A (BPA) is a plasticiser found in a number of household plastics, electronics, and food-packaging materials. Over the past 5 years, several human epidemiological studies have reported a positive association between BPA exposure and adverse health outcomes in children, including obesity, asthma, preterm birth, and neuro-behavioural disturbances. These findings are in conflict with international environmental risk assessment models, which predict daily exposure levels to BPA should not pose a risk to child health. The aim of this review is to provide an overview of the evidence for different exposure sources and potential exposure pathways of BPA in early childhood. By collating the findings from experimental models and exposure associations observed in human bio-monitoring studies, we affirm the potential for non-dietary sources to make a substantial contribution to total daily exposure in young children. Infants and toddlers have distinctive exposure sources, physiology, and metabolism of endocrine-disrupting chemicals. We recommend risk-assessment models implement new frameworks, which specifically address exposure and hazard in early childhood. This is particularly important for BPA, which is present in numerous products in the home and day-care environments, and for which animal studies report contradictory findings on its safety at environmentally relevant levels of exposure.
Keyword Bisphenol A
Child health
Environmental health
Exposure assessment
Exposure pathway
Risk assessment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Public Health Publications
School of Medicine Publications
Child Health Research Centre Publications
 
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