Prognostic value of circulating cytokines on overall survival and disease-free survival in cancer patients

Visconti, Laura, Nelissen, Katherine, Deckx, Laura, van den Akker, Marjan, Adriaensen, Wim, Daniels, Liesbeth, Mathei, Cathy, Linsen, Loes, Hellings, Niels, Stinissen, Piet and Buntinx, Frank (2014) Prognostic value of circulating cytokines on overall survival and disease-free survival in cancer patients. Biomarkers in Medicine, 8 2: 297-306. doi:10.2217/bmm.13.122


Author Visconti, Laura
Nelissen, Katherine
Deckx, Laura
van den Akker, Marjan
Adriaensen, Wim
Daniels, Liesbeth
Mathei, Cathy
Linsen, Loes
Hellings, Niels
Stinissen, Piet
Buntinx, Frank
Title Prognostic value of circulating cytokines on overall survival and disease-free survival in cancer patients
Journal name Biomarkers in Medicine   Check publisher's open access policy
ISSN 1752-0363
1752-0371
Publication date 2014
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2217/bmm.13.122
Volume 8
Issue 2
Start page 297
End page 306
Total pages 10
Place of publication London, United Kingdom
Publisher Future Medicine
Collection year 2015
Language eng
Abstract Through their tumor-promoting and/or tumor-suppressive properties, cytokines can influence progression of cancer. We systematically reviewed the current literature on the prognostic value of the circulating cytokines IL-1α/, IL-6, IL-8, IL-10, IL-12, TNF-α, TGF- and IFN- to predict overall and disease-free survival in any type of cancer patients. PubMed was systematically searched and based on eligibility assessment using our five criteria of the Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK) checklist, six unique studies were reviewed. Elevated IL-6 and IL-10 levels seem independently associated with worse prognosis in terms of overall and disease-free survival. The prognostic value of IL-1α/, IL-8, IL-12, TNF-α, TGF- and IFN- could not be demonstrated. The small number of selected studies underlines the need for large well-designed prospective studies, using the REMARK checklist as a guideline, to determine which cytokines have prognostic value on survival in cancer patients.
Keyword Cytokines
Mortality
Neoplasms
Prognosis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Discipline of General Practice Publications
 
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Created: Thu, 17 Sep 2015, 10:15:00 EST by Anthony Yeates on behalf of Discipline of General Practice