Effect of Tubing on Loss of Clonazepam Administered by Continuous Subcutaneous Infusion

Schneider, Jennifer J., Good, Phillip and Ravenscroft, Peter J. (2006) Effect of Tubing on Loss of Clonazepam Administered by Continuous Subcutaneous Infusion. Journal of Pain and Symptom Management, 31 6: 563-567. doi:10.1016/j.jpainsymman.2005.09.008


Author Schneider, Jennifer J.
Good, Phillip
Ravenscroft, Peter J.
Title Effect of Tubing on Loss of Clonazepam Administered by Continuous Subcutaneous Infusion
Journal name Journal of Pain and Symptom Management   Check publisher's open access policy
ISSN 0885-3924
Publication date 2006
Sub-type Article (original research)
DOI 10.1016/j.jpainsymman.2005.09.008
Volume 31
Issue 6
Start page 563
End page 567
Total pages 5
Language eng
Subject 2703 Anesthesiology and Pain Medicine
2728 Clinical Neurology
2808 Neurology
2900 Nursing
Abstract Previous studies have reported loss of clonazepam from solutions administered intravenously from plastic infusion bags and administration sets. In palliative care, clonazepam is sometimes administered through syringe drivers using polyvinyl chloride (PVC) infusion tubing. No data currently exist to show whether use of PVC tubing affects the amount of clonazepam actually received by the patient. This study compared the use of two different types of PVC tubing with a non-PVC tubing. Solutions containing clonazepam or clonazepam and morphine were prepared with either normal saline or water for injection as diluent. Concentrations of morphine and clonazepam were determined using high-performance liquid chromatography. Significant loss of clonazepam (up to 50%) was observed in all solutions infused through PVC tubing. Solutions infused through non-PVC tubing retained greater than 90% of the initial concentration of clonazepam. It is recommended that when administering clonazepam using a syringe driver, non-PVC tubing be used.
Keyword clonazepam
morphine sulfate
palliative care
sorption
stability
Subcutaneous drug administration
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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