The contributions of plasma IGF-I, IGFBP-3 and leptin to growth in extremely premature infants during the first two years

Patel, Leena, Cavazzoni, Elena, Whatmore, Andrew J., Carney, Sally, Wales, Jeremy K., Clayton, Peter E. and Gibson, Alan T. (2007) The contributions of plasma IGF-I, IGFBP-3 and leptin to growth in extremely premature infants during the first two years. Pediatric Research, 61 1: 99-104. doi:10.1203/01.pdr.0000250036.34522.f1


Author Patel, Leena
Cavazzoni, Elena
Whatmore, Andrew J.
Carney, Sally
Wales, Jeremy K.
Clayton, Peter E.
Gibson, Alan T.
Title The contributions of plasma IGF-I, IGFBP-3 and leptin to growth in extremely premature infants during the first two years
Journal name Pediatric Research   Check publisher's open access policy
ISSN 0031-3998
Publication date 2007
Sub-type Article (original research)
DOI 10.1203/01.pdr.0000250036.34522.f1
Volume 61
Issue 1
Start page 99
End page 104
Total pages 6
Language eng
Subject 2735 Pediatrics, Perinatology, and Child Health
Abstract We determined the contributions of IGF-I, IGFBP-3 and leptin to growth in -extremely premature infants over the first two years. Weight (Wt), crown-to heel length (CHL), plasma IGF-I, IGFBP-3 and leptin were measured in infants (gestation 24-33 wk) at birth (n ≤ 54), expected date of delivery (EDD) and 6, 12 and 24 mo post-EDD (n ≤ 29). Area under the curve (AUC) for hormone levels was calculated over 4 periods: birth-EDD, EDD-200 d, EDD-350 d and EDD-700 d. IGFBP-3, but not IGF-I or leptin, on day 1 correlated with birth Wt SD scores (SDS) (r ≤ 0.46, p ≤ 0.002) and CHL SDS (r ≤ 0.41, p ≤ 0.01). Wt SDS at EDD correlated with AUC IGF-I, IGFBP-3 and leptin (birth-EDD), but leptin was the best predictor in multiple regression(r ≤ 0.65, p < 0.0001). Wt at EDD + 700 d correlated with AUC leptin (EDD-700 d) (r ≤ 0.62, p ≤ 0.002). CHL SDS at EDD correlated with AUC IGFBP-3 and leptin (birth-EDD), but IGFBP-3 was the best predictor (r ≤ 0.55, p < 0.0001). CHL at EDD + 700 d correlated with AUC IGF-I and IGFBP-3 (EDD-700 d), but IGFBP-3 was the best predictor (r ≤ 0.47, p ≤ 0.01). Wt and CHL at birth were associated with IGFBP-3 levels in these infants. Wt at EDD and EDD + 700 d was predicted by concurrent leptin output while linear growth at EDD and EDD + 700 d was predicted by IGFBP-3 output. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

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Sub-type: Article (original research)
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