Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease

Grande-Allen, K. J., Osman, N., Ballinger, M. L., Dadlani, H., Marasco, S. and Little, P. J. (2007) Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease. Cardiovascular Research, 76 1: 19-28. doi:10.1016/j.cardiores.2007.05.014


Author Grande-Allen, K. J.
Osman, N.
Ballinger, M. L.
Dadlani, H.
Marasco, S.
Little, P. J.
Title Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease
Journal name Cardiovascular Research   Check publisher's open access policy
ISSN 0008-6363
1755-3245
Publication date 2007-10-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.cardiores.2007.05.014
Open Access Status Not yet assessed
Volume 76
Issue 1
Start page 19
End page 28
Total pages 10
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Abstract Calcific aortic valve disease is frequently driven by ageing and the obesity-associated metabolic syndrome, and the increasing impact of these factors indicates that valve disease will become a cardiovascular disease of considerable significance. This disease is now thought to be an active cell-based disease process, which may therefore be amenable to therapeutic intervention. Some similarities are apparent with atherosclerosis. The accumulation of lipid, possibly by retention by proteoglycans and the attraction of inflammatory cells by hyaluronan, may be common to the early stages of both pathologies. The synthesis and structure of glycosaminoglycans, proteoglycans, and hyaluronan are exquisitely regulated, and the signalling pathways controlling these processes may provide tissue-specific opportunities for concomitant prevention of atherosclerosis and calcific aortic valve disease.
Keyword Calcific aortic valve disease
Hyaluronan
Inflammation
Lipid retention
Proteoglycans
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Pharmacy Publications
 
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