Nerve growth factor protects retinal ganglion cells against injury induced by retinal ischemia-reperfusion in rats

Chen, Qian, Wang, Haitao, Liao, Sufen, Gao, Yang, Liao, Rifang, Little, Peter J., Xu, Jiangping, Feng, Zhong-Ping, Zheng, Yongxin and Zheng, Wenhua (2015) Nerve growth factor protects retinal ganglion cells against injury induced by retinal ischemia-reperfusion in rats. Growth Factors, 33 2: 149-159. doi:10.3109/08977194.2015.1010642


Author Chen, Qian
Wang, Haitao
Liao, Sufen
Gao, Yang
Liao, Rifang
Little, Peter J.
Xu, Jiangping
Feng, Zhong-Ping
Zheng, Yongxin
Zheng, Wenhua
Title Nerve growth factor protects retinal ganglion cells against injury induced by retinal ischemia-reperfusion in rats
Journal name Growth Factors   Check publisher's open access policy
ISSN 1029-2292
0897-7194
Publication date 2015-02-24
Year available 2015
Sub-type Article (original research)
DOI 10.3109/08977194.2015.1010642
Open Access Status Not Open Access
Volume 33
Issue 2
Start page 149
End page 159
Total pages 11
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2016
Language eng
Abstract In this study, we investigated the protective effect of mouse nerve growth factor (NGF) on retinal ganglion cell (RGC) injury induced by retinal ischemia–reperfusion (RIR) in rats and explored its possible mechanisms of action. RIR caused a significant injury to RGCs and an obvious impairment of the inner retina functions, which could be seen from flash electroretinogram and flash visual evoked potential recordings. RIR also increased the expression of the apoptotic protein Bax while decreasing the expression of Bcl-2 and the phosphorylation of protein kinase B (Akt) in RGCs. Preinjection (i.m.) of NGF for 22 d reversed the injury induced by RIR and ameliorated the inner retina functions. NGF also reduced the expression of Bax and reversed the reduction of Bcl-2 and the phosphorylated Akt induced by RIR. These results indicate that NGF produces a neuroprotective effect on RGCs against RIR injury and the protective effect of NGF is mainly mediated by the PI-3K/Akt signaling pathway.
Keyword Nerve growth factor
PI-3K/Akt signaling pathway
Retinal ischemia-reperfusion
Retinal ganglion cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Pharmacy Publications
 
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