Thrombin-mediated proteoglycan synthesis utilizes both protein-tyrosine kinase and serine/threonine kinase receptor transactivation in vascular smooth muscle cells

Burch, Micah L., Getachew, Robel, Osman, Narin, Febbraio, Mark A. and Little, Peter J. (2013) Thrombin-mediated proteoglycan synthesis utilizes both protein-tyrosine kinase and serine/threonine kinase receptor transactivation in vascular smooth muscle cells. Journal of Biological Chemistry, 288 10: 7410-7419. doi:10.1074/jbc.M112.400259

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Author Burch, Micah L.
Getachew, Robel
Osman, Narin
Febbraio, Mark A.
Little, Peter J.
Title Thrombin-mediated proteoglycan synthesis utilizes both protein-tyrosine kinase and serine/threonine kinase receptor transactivation in vascular smooth muscle cells
Journal name Journal of Biological Chemistry   Check publisher's open access policy
ISSN 0021-9258
Publication date 2013-03-08
Sub-type Article (original research)
DOI 10.1074/jbc.M112.400259
Open Access Status File (Publisher version)
Volume 288
Issue 10
Start page 7410
End page 7419
Total pages 10
Place of publication Bethesda, MD, United States
Publisher American Society for Biochemistry and Molecular Biology
Language eng
Abstract Background: GPCR transactivation of PTKRs and TGF-αRs mediates proteoglycan synthesis in human VSMC. Results: Transactivation of TGF-αRs is integrin-dependent, and inhibition of both transactivation pathways blocks proteoglycan synthesis. Conclusion: GPCR utilize transactivation pathways and not classical signaling in proteoglycan synthesis. Significance: GPCR transactivation of receptor kinase pathways may be broader and more significant than previously recognized.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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