Nedd4 and Nedd4-2: Ubiquitin ligases at work in the neuron

Donovan, Prudence and Poronnik, Philip (2013) Nedd4 and Nedd4-2: Ubiquitin ligases at work in the neuron. International Journal of Biochemistry and Cell Biology, 45 3: 706-710. doi:10.1016/j.biocel.2012.12.006


Author Donovan, Prudence
Poronnik, Philip
Title Nedd4 and Nedd4-2: Ubiquitin ligases at work in the neuron
Journal name International Journal of Biochemistry and Cell Biology   Check publisher's open access policy
ISSN 1357-2725
1878-5875
Publication date 2013
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.biocel.2012.12.006
Volume 45
Issue 3
Start page 706
End page 710
Total pages 5
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Abstract Ubiquitination of proteins by the Nedd4 family of ubiquitin ligases is a significant mechanism in protein trafficking and degradation and provides for tight spatiotemporal regulation. Ubiquitination is gaining increasing recognition as a central mechanism underpinning the regulation of neuronal development and homeostasis in the brain. This review will focus on the Nedd4 and Nedd4-2 E3 ubiquitin ligases that are implicated in an increasing number of neuronal protein-protein interactions. Understanding of the contribution of Nedd4 and Nedd4-2 in regulating key functions in the brain is shedding new light on the ubiquitination signal not only in orchestrating degradation events but also in protein trafficking. Furthermore, the description of several novel Nedd4/4-2 targets in neurons is changing the way we conceptualize how neurons maintain normal function and how this is altered in disease.
Keyword Nedd4
Nedd4 2
Neurons
Trafficking
Ubiquitination
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Tue, 15 Sep 2015, 10:51:09 EST by Prudence Donovan on behalf of UQ Diamantina Institute