Cortical burst dynamics predict clinical outcome early in extremely preterm infants

Iyer, Kartik K., Roberts, James A., Hellstrom-Westas, Lena., Wikstrom, Sverre., Hansen Pupp, Ingrid., Ley, David., Vanhatalo, Sampsa. and Breakspear, Michael. (2015) Cortical burst dynamics predict clinical outcome early in extremely preterm infants. Brain, 138 8: 2206-2218. doi:10.1093/brain/awv129


Author Iyer, Kartik K.
Roberts, James A.
Hellstrom-Westas, Lena.
Wikstrom, Sverre.
Hansen Pupp, Ingrid.
Ley, David.
Vanhatalo, Sampsa.
Breakspear, Michael.
Title Cortical burst dynamics predict clinical outcome early in extremely preterm infants
Journal name Brain   Check publisher's open access policy
ISSN 1460-2156
0006-8950
Publication date 2015-05-23
Year available 2015
Sub-type Article (original research)
DOI 10.1093/brain/awv129
Open Access Status Not Open Access
Volume 138
Issue 8
Start page 2206
End page 2218
Total pages 13
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2016
Language eng
Formatted abstract
Intermittent bursts of electrical activity are a ubiquitous signature of very early brain activity. Previous studies have largely focused on assessing the amplitudes of these transient cortical bursts or the intervals between them. Recent advances in basic neuroscience have identified the presence of scale-free ‘avalanche’ processes in bursting patterns of cortical activity in other clinical contexts. Here, we hypothesize that cortical bursts in human preterm infants also exhibit scale-free properties, providing new insights into the nature, temporal evolution, and prognostic value of spontaneous brain activity in the days immediately following preterm birth. We examined electroencephalographic recordings from 43 extremely preterm infants (gestational age 22–28 weeks) and demonstrated that their cortical bursts exhibit scale-free properties as early as 12 h after birth. The scaling relationships of cortical bursts correlate significantly with later mental development—particularly within the first 12 h of life. These findings show that early preterm brain activity is characterized by scale-free dynamics which carry developmental significance, hence offering novel means for rapid and early clinical prediction of neurodevelopmental outcomes.
Keyword Preterm
Scale-freebursts
Spontaneous activity transient
Long-term outcome
Brain monitoring
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 15 Sep 2015, 02:33:04 EST by System User on behalf of Scholarly Communication and Digitisation Service