The metastability and nucleation thresholds of ibuprofen in ethanol and water-ethanol mixtures

Rashid, Abdur., White, Edward T., Howes, Tony., Litster, James D. and Marziano, Ivan. (2015) The metastability and nucleation thresholds of ibuprofen in ethanol and water-ethanol mixtures. International Journal of Chemical Engineering, 2015 . doi:10.1155/2015/560930


Author Rashid, Abdur.
White, Edward T.
Howes, Tony.
Litster, James D.
Marziano, Ivan.
Title The metastability and nucleation thresholds of ibuprofen in ethanol and water-ethanol mixtures
Journal name International Journal of Chemical Engineering   Check publisher's open access policy
ISSN 1687-8078
1687-806X
Publication date 2015-01-01
Year available 2015
Sub-type Article (original research)
DOI 10.1155/2015/560930
Open Access Status DOI
Volume 2015
Total pages 7
Place of publication New York, United States
Publisher Hindawi Publishing Corporation
Collection year 2016
Language eng
Formatted abstract
To investigate the crystallization of ibuprofen [((RS)-2-(4-(2-methylpropyl) phenyl) propanoic acid)] from ethanol and water-ethanol mixtures it is necessary to know the nucleation limits of its solutions. In the absence of crystals, nucleation will seldom occur below the PNT (primary nucleation threshold). If crystals are present, nucleation will seldom occur until below the lower SNT (secondary nucleation threshold). Below the SNT, crystals will still grow with negligible nucleation. PNT and SNT values (expressed as relative supersaturation σ) have been measured at 10, 25, and 40°C for ibuprofen in ethanol and in a range of mixtures of different ethanol (E)/water (W) ratios. The induction times were determined from observing the times to nucleate for a range of different supersaturated solutions at a given temperature and E/W ratio. As expected, lowering the supersaturation leads to longer induction times. In ethanol, the SNT values are small and thus the secondary metastable zone width (MSZW) is relatively narrow with a 1 h SNT relative supersaturation typically about σ ~ 0.05. The 1 h PNT values are much larger with values for σ around 0.3. In aqueous ethanolic mixtures at 25°C, both the PNT and SNT decrease as the water content increases.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Chemical Engineering Publications
Official 2016 Collection
 
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