Reduced risk of pertussis in whole-cell compared to acellular vaccine recipients is not confounded by age or receipt of booster-doses

Sheridan, Sarah L., Ware, Robert S., Grimwood, Keith and Lambert, Stephen B. (2015) Reduced risk of pertussis in whole-cell compared to acellular vaccine recipients is not confounded by age or receipt of booster-doses. Vaccine, 33 39: 5027-5030. doi:10.1016/j.vaccine.2015.08.021


Author Sheridan, Sarah L.
Ware, Robert S.
Grimwood, Keith
Lambert, Stephen B.
Title Reduced risk of pertussis in whole-cell compared to acellular vaccine recipients is not confounded by age or receipt of booster-doses
Journal name Vaccine   Check publisher's open access policy
ISSN 1873-2518
0264-410X
Publication date 2015-09-22
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2015.08.021
Open Access Status Not Open Access
Volume 33
Issue 39
Start page 5027
End page 5030
Total pages 5030
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2016
Language eng
Abstract Several observational studies provide evidence that acellular pertussis vaccines (aP) are less protective against pertussis disease than highly effective whole-cell pertussis vaccines (wP), however, concerns have been raised that some of these findings may be confounded by age. By undertaking age-stratified and restricted analyses on a cohort of Australian children primed with either aP-only, wP-only or mixed pertussis vaccine schedules, we demonstrate that compared to aP the association of wP with increased protection from pertussis is not confounded by age, nor by aP booster-dose receipt.
Keyword Pertussis
Whole-cell pertussis vaccine
Acellular pertussis vaccine
Vaccine effectiveness
Confounding
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 15 Sep 2015, 01:42:55 EST by System User on behalf of Scholarly Communication and Digitisation Service