Developmental trajectories of adiposity from birth until early adulthood and association with cardiometabolic risk factors

Araujo, J., Severo, M., Barros, H., Mishra, G. D., Guimaraes, J. T. and Ramos, E. (2015) Developmental trajectories of adiposity from birth until early adulthood and association with cardiometabolic risk factors. International Journal of Obesity, 39 10: 1443-1449. doi:10.1038/ijo.2015.128


Author Araujo, J.
Severo, M.
Barros, H.
Mishra, G. D.
Guimaraes, J. T.
Ramos, E.
Title Developmental trajectories of adiposity from birth until early adulthood and association with cardiometabolic risk factors
Journal name International Journal of Obesity   Check publisher's open access policy
ISSN 0307-0565
1476-5497
Publication date 2015-09-08
Sub-type Article (original research)
DOI 10.1038/ijo.2015.128
Volume 39
Issue 10
Start page 1443
End page 1449
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2016
Language eng
Formatted abstract
Objective: To identify developmental trajectories of adiposity from birth until early adulthood, and to investigate how they relate with cardiometabolic risk factors at 21 years of age.

Methods: Participants’ weight and height measurements were obtained using the EPITeen cohort protocol at 13, 17 and 21 years of age, and extracted from child health books as recorded during health routine evaluations since birth. Blood pressure, triglycerides, cholesterol and insulin resistance (HOMA-IR) were assessed at 21 years. Trajectories were defined using 719 participants contributing 11 459 measurements. The individual growth curves were modelled using mixed-effects fractional polynomial, and the trajectories were estimated using normal mixture modelling for model-based clustering. Differences in cardiometabolic risk factors at 21 years according to adiposity trajectories were estimated through analysis of covariance (ANCOVA), and adjusted means are presented.

Results: Two trajectories—‘Average body mass index (BMI) growth’ (80.7%) and ‘Higher BMI growth’ (19.3%)—were identified. Compared with those in ‘Average BMI growth’, ‘Higher BMI growth’ participants were more frequently delivered by caesarean section, mothers were younger and had higher BMI, and parental education was lower; and at 21 years showed higher adjusted mean systolic (111.6 vs 108.3 mm Hg, P<0.001) and diastolic blood pressure (71.9 vs 68.4 mm Hg, P<0.001), and lower high-density lipoprotein cholesterol (53.3 vs 57.0 mg dl−1, P=0.001). As there was a significant interaction between trajectories and sex, triglycerides and HOMA-IR were stratified by sex and we found significantly higher triglycerides, in males, and higher HOMA-IR in both sexes in ‘Higher BMI growth’ trajectory. All the differences were attenuated after adjustment for BMI at 21 years.

Conclusions: In this long-term follow-up, we were able to identify two adiposity trajectories, statistically related to the BMI and cardiometabolic profile in adulthood. Our results also suggest that the impact of the adiposity trajectory on cardiometabolic profile is mediated by current BMI.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Public Health Publications
 
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