Endosome escape strategies for improving the efficacy of oligonucleotide delivery systems

Wan, Yu, Moyle, Peter M and Toth, Istvan (2015) Endosome escape strategies for improving the efficacy of oligonucleotide delivery systems. Current Medicinal Chemistry, 22 29: 3326-3346. doi:10.2174/0929867322666150825162941

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Author Wan, Yu
Moyle, Peter M
Toth, Istvan
Title Endosome escape strategies for improving the efficacy of oligonucleotide delivery systems
Journal name Current Medicinal Chemistry   Check publisher's open access policy
ISSN 0929-8673
1875-533X
Publication date 2015-09-01
Sub-type Article (original research)
DOI 10.2174/0929867322666150825162941
Open Access Status Not Open Access
Volume 22
Issue 29
Start page 3326
End page 3346
Total pages 21
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2016
Language eng
Abstract Gene therapy requires safe and effective vectors to deliver genes to their target site of action. Non-viral gene delivery systems have attracted growing attention due to their low toxicity, low immunogenicity and ease of production compared to viral vectors. Most non-viral gene delivery systems enter cells via endocytic pathways, and their escape from endosomes is therefore a crucial for successful transfection. Several reagents have been developed to promote endosomal escape, including peptides, polymers and lipids. Among these, endosome-disrupting peptides have been used in many studies, and have proven to be one of the most promising approaches to overcome endosomal entrapment and lysosomal degradation. This review provides an up-to-date summary of strategies for enhancing endosomal escape, with a focus on the modification of endosome-disrupting peptides to further increase the efficient delivery of oligonucleotides.
Keyword Endosome escape
Fusogenic peptides
Gene delivery
Non-viral vectors
Oligonucleotides
Peptides
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Pharmacy Publications
 
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Created: Tue, 15 Sep 2015, 01:36:34 EST by Peter Moyle on behalf of School of Pharmacy