Interleukin-21-producing CD4+ T cells promote type 2 immunity to house dust mites

Coquet, Jonathan M., Schuijs, Martijn J., Smyth, Mark J., Deswarte, Kim, Beyaert, Rudi, Braun, Harald, Boon, Louis, Hedestam, Gunilla B. Karlsson, Nutt, Steven L., Hammad, Hamida and Lambrecht, Bart N. (2015) Interleukin-21-producing CD4+ T cells promote type 2 immunity to house dust mites. Immunity, 43 2: 318-330. doi:10.1016/j.immuni.2015.07.015


Author Coquet, Jonathan M.
Schuijs, Martijn J.
Smyth, Mark J.
Deswarte, Kim
Beyaert, Rudi
Braun, Harald
Boon, Louis
Hedestam, Gunilla B. Karlsson
Nutt, Steven L.
Hammad, Hamida
Lambrecht, Bart N.
Title Interleukin-21-producing CD4+ T cells promote type 2 immunity to house dust mites
Formatted title
Interleukin-21-producing CD4+ T cells promote type 2 immunity to house dust mites
Journal name Immunity   Check publisher's open access policy
ISSN 1074-7613
1097-4180
Publication date 2015-08-18
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.immuni.2015.07.015
Open Access Status Not Open Access
Volume 43
Issue 2
Start page 318
End page 330
Total pages 13
Place of publication Cambridge, MA United States
Publisher Cell Press
Collection year 2016
Language eng
Formatted abstract
Asthma is a T helper 2 (Th2)-cell-mediated disease; however, recent findings implicate Th17 and innate lymphoid cells also in regulating airway inflammation. Herein, we have demonstrated profound interleukin-21 (IL-21) production after house dust mite (HDM)-driven asthma by using T cell receptor (TCR) transgenic mice reactive to Dermatophagoides pteronyssinus 1 and an IL-21GFP reporter mouse. IL-21-producing cells in the mediastinal lymph node (mLN) bore characteristics of T follicular helper (Tfh) cells, whereas IL-21+ cells in the lung did not express CXCR5 (a chemokine receptor expressed by Tfh cells) and were distinct from effector Th2 or Th17 cells. Il21r−/− mice developed reduced type 2 responses and the IL-21 receptor (IL-21R) enhanced Th2 cell function in a cell-intrinsic manner. Finally, administration of recombinant IL-21 and IL-25 synergistically promoted airway eosinophilia primarily via effects on CD4+ lymphocytes. This highlights an important Th2-cell-amplifying function of IL-21-producing CD4+ T cells in allergic airway inflammation.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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