Folates of rat tissue. Bioassay of tissue folypolyglutamates and a relationship of liver folypolyglutamates to nutritional folate sufficiency

Richardson, RE, Healy, MJ and Nixon, PF (1979) Folates of rat tissue. Bioassay of tissue folypolyglutamates and a relationship of liver folypolyglutamates to nutritional folate sufficiency. BBA - General Subjects, 585 1: 128-133. doi:10.1016/0304-4165(79)90332-5


Author Richardson, RE
Healy, MJ
Nixon, PF
Title Folates of rat tissue. Bioassay of tissue folypolyglutamates and a relationship of liver folypolyglutamates to nutritional folate sufficiency
Journal name BBA - General Subjects   Check publisher's open access policy
ISSN 0304-4165
Publication date 1979-06-01
Sub-type Article (original research)
DOI 10.1016/0304-4165(79)90332-5
Volume 585
Issue 1
Start page 128
End page 133
Total pages 6
Language eng
Subject 1303 Specialist Studies in Education
1304 Biophysics
1312 Molecular Biology
2700 Medicine
Abstract The folate content of young rat tissues extracted into boiling ascorbate was assayed by Lactobactillus casei both without and after treatment by a folate-free preparation of conjugase. The total folate content of various tissues was: liver, 8.9 μg/g; kidney, 2.6; adrenal, 2.6; bone marrow, 2.4; spleen, 0.9; erythrocytes, 0.8; small intestinal mucosa, 0.7; small intestinal smooth muscle, 0.8; heart, 0.6; brain, 0.4, and skeletal muscle, 0.1 μg/g tissue. For most tissues, with the exception of muscle and kidney, approximately 80% of the total folates assayed as longer chain length folylpolyglutamates. When liver folates were analyzed from rats fed folate-supplemented, control and folate-deficient diets, a relationship was found between folate nutrition and distribution of folylpolyglutamates. The proportion of total folates in the form of longer chain length folylpolyglutamates was greatest in the livers of folate-deficient rats and least in the livers of folate-supplemented rats.
Keyword Folate assay
Folylpolyglutamate
Nutrition
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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