Community-acquired pyelonephritis in pregnancy caused by KPC-producing Klebsiella pneumoniae

Khatri, Asma, Murphy, Nina Naeger, Wiest, Peter, Osborn, Melissa, Garber, Kathleen, Hecker, Michelle, Hurless, Kelly, Rudin, Susan D., Jacobs, Michael R., Kalayjian, Robert C., Salata, Robert A., Van Duin, David, Perez, Federico, Bonomob, Robert A., Paterson, David L. and Harris, Patrick N. A. (2015) Community-acquired pyelonephritis in pregnancy caused by KPC-producing Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy, 59 8: 4375-4378. doi:10.1128/AAC.00553-15

Author Khatri, Asma
Murphy, Nina Naeger
Wiest, Peter
Osborn, Melissa
Garber, Kathleen
Hecker, Michelle
Hurless, Kelly
Rudin, Susan D.
Jacobs, Michael R.
Kalayjian, Robert C.
Salata, Robert A.
Van Duin, David
Perez, Federico
Bonomob, Robert A.
Paterson, David L.
Harris, Patrick N. A.
Title Community-acquired pyelonephritis in pregnancy caused by KPC-producing Klebsiella pneumoniae
Journal name Antimicrobial Agents and Chemotherapy   Check publisher's open access policy
ISSN 1098-6596
Publication date 2015-08
Sub-type Article (original research)
DOI 10.1128/AAC.00553-15
Open Access Status DOI
Volume 59
Issue 8
Start page 4375
End page 4378
Total pages 4
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2016
Language eng
Formatted abstract
Carbapenem-resistant Enterobacteriaceae (CRE) usually infect patients with significant comorbidities and health care exposures. We present a case of a pregnant woman who developed community-acquired pyelonephritis caused by KPC-producing Klebsiella pneumoniae. Despite antibiotic treatment, she experienced spontaneous prolonged rupture of membranes, with eventual delivery of a healthy infant. This report demonstrates the challenge that CRE may pose to the effective treatment of common infections in obstetric patients, with potentially harmful consequences to maternal and neonatal health.

This Journal section presents a real, challenging case involving a multidrug-resistant organism. The case authors present the rationale for their therapeutic strategy and discuss the impact of mechanisms of resistance on clinical outcome. An expert clinician then provides a commentary on the case.
Keyword Enterobacteriaceae infections
Klebsiella pneumoniae
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
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