Forkhead box O transcription factors as possible mediators in the development of major depression

Wang, Haitao, Quirion, Remi, Little, Peter J., Cheng, Yufang, Feng, Zhong-Ping, Sun, Hong-Shuo, Xu, Jiangping and Zheng, Wenhua (2015) Forkhead box O transcription factors as possible mediators in the development of major depression. Neuropharmacology, 99 527-537. doi:10.1016/j.neuropharm.2015.08.020

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Author Wang, Haitao
Quirion, Remi
Little, Peter J.
Cheng, Yufang
Feng, Zhong-Ping
Sun, Hong-Shuo
Xu, Jiangping
Zheng, Wenhua
Title Forkhead box O transcription factors as possible mediators in the development of major depression
Journal name Neuropharmacology   Check publisher's open access policy
ISSN 1873-7064
0028-3908
Publication date 2015-12-27
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.neuropharm.2015.08.020
Open Access Status File (Author Post-print)
Volume 99
Start page 527
End page 537
Total pages 11
Place of publication Kidlington, Oxford United Kingdom
Publisher Pergamon Press
Collection year 2016
Language eng
Abstract Forkhead box O (FoxO) transcription factors play important roles in cellular physiology and biology. Recent findings indicate that FoxOs are also involved in the development of major depressive disorder. Alterations in the upstream molecules of FoxOs, such as brain derived neurotrophic factor or protein kinase B, have been linked to depression. Antidepressants, such as imipramine and venlafaxine, modify the FoxOs phosphorylation. Furthermore, FoxOs could be regulated by serotonin and norepinephrine receptor signaling as well as the hypothalamic–pituitary–adrenal axis, all of which are involved in the pathogenesis of depression. FoxOs also regulate neuronal morphology, synaptogenesis and adult hippocampal neurogenesis, which are viewed as candidate mechanisms for the etiology of depression. In this review, we emphasize the possible roles of FoxOs during the development of depression and make some strategic recommendations for future research. We propose that FoxOs and its signaling pathways may constitute potential therapeutic targets in the treatment of depression.
Keyword FoxO
Major depression
PI3K/Akt
Neuronal atrophy
Neurogenesis
Antidepressants
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Pharmacy Publications
 
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