Whole-genome sequence of Schistosoma haematobium

Young, Neil D., Jex, Aaron R., Li, Bo, Liu, Shiping, Yang, Linfeng, Xiong, Zijun, Li, Yingrui, Cantacessi, Cinzia, Hall, Ross S., Xu, Xun, Chen, Fangyuan, Wu, Xuan, Zerlotini, Adhemar, Oliveira, Guilherme, Hofmann, Andreas, Zhang, Guojie, Fang, Xiaodong, Kang, Yi, Campbell, Bronwyn E., Loukas, Alex, Ranganathan, Shoba, Rollinson, David, Rinaldi, Gabriel, Brindley, Paul J., Yang, Huanming, Wang, Jun, Wang, Jian and Gasser, Robin B. (2012) Whole-genome sequence of Schistosoma haematobium. Nature Genetics, 44 2: 221-225. doi:10.1038/ng.1065

Author Young, Neil D.
Jex, Aaron R.
Li, Bo
Liu, Shiping
Yang, Linfeng
Xiong, Zijun
Li, Yingrui
Cantacessi, Cinzia
Hall, Ross S.
Xu, Xun
Chen, Fangyuan
Wu, Xuan
Zerlotini, Adhemar
Oliveira, Guilherme
Hofmann, Andreas
Zhang, Guojie
Fang, Xiaodong
Kang, Yi
Campbell, Bronwyn E.
Loukas, Alex
Ranganathan, Shoba
Rollinson, David
Rinaldi, Gabriel
Brindley, Paul J.
Yang, Huanming
Wang, Jun
Wang, Jian
Gasser, Robin B.
Title Whole-genome sequence of Schistosoma haematobium
Formatted title
Whole-genome sequence of Schistosoma haematobium
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2012-02
Year available 2012
Sub-type Article (original research)
DOI 10.1038/ng.1065
Open Access Status DOI
Volume 44
Issue 2
Start page 221
End page 225
Total pages 5
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Formatted abstract
Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are available, and treatment relies on one drug, praziquantel. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer and as a predisposing factor for HIV/AIDS. The parasite is transmitted to humans from freshwater snails. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease and induce squamous cell carcinoma. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites. We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 153 times in Thomson Reuters Web of Science Article | Citations
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