Ancient human genome sequence of an extinct Palaeo-Eskimo

Rasmussen, Morten, Li, Yingrui, Lindgreen, Stinus, Pedersen, Jakob Skou, Albrechtsen, Anders, Moltke, Ida, Metspalu, Mait, Metspalu, Ene, Kivisild, Toomas, Gupta, Ramneek, Bertalan, Marcelo, Nielsen, Kasper, Gilbert, M. Thomas P., Wang, Yong, Raghavan, Maanasa, Campos, Paula F., Kamp, Hanne Munkholm, Wilson, Andrew S., Gledhill, Andrew, Tridico, Silvana, Bunce, Michael, Lorenzen, Eline D., Binladen, Jonas, Guo, Xiaosen, Zhao, Jing, Zhang, Xiuqing, Zhang, Hao, Li, Zhuo, Chen, Minfeng, Orlando, Ludovic, Kristiansen, Karsten, Bak, Mads, Tommerup, Niels, Bendixen, Christian, Pierre, Tracey L., Gronnow, Bjarne, Meldgaard, Morten, Andreasen, Claus, Fedorova, Sardana A., Osipova, Ludmila P., Higham, Thomas F. G., Ramsey, Christopher Bronk, Hansen, Thomas V. O., Nielsen, Finn C., Crawford, Michael H., Brunak, Soren, Sicheritz-Ponten, Thomas, Villems, Richard, Nielsen, Rasmus, Krogh, Anders, Wang, Jun and Willerslev, Eske (2010) Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature, 463 7282: 757-762. doi:10.1038/nature08835

Author Rasmussen, Morten
Li, Yingrui
Lindgreen, Stinus
Pedersen, Jakob Skou
Albrechtsen, Anders
Moltke, Ida
Metspalu, Mait
Metspalu, Ene
Kivisild, Toomas
Gupta, Ramneek
Bertalan, Marcelo
Nielsen, Kasper
Gilbert, M. Thomas P.
Wang, Yong
Raghavan, Maanasa
Campos, Paula F.
Kamp, Hanne Munkholm
Wilson, Andrew S.
Gledhill, Andrew
Tridico, Silvana
Bunce, Michael
Lorenzen, Eline D.
Binladen, Jonas
Guo, Xiaosen
Zhao, Jing
Zhang, Xiuqing
Zhang, Hao
Li, Zhuo
Chen, Minfeng
Orlando, Ludovic
Kristiansen, Karsten
Bak, Mads
Tommerup, Niels
Bendixen, Christian
Pierre, Tracey L.
Gronnow, Bjarne
Meldgaard, Morten
Andreasen, Claus
Fedorova, Sardana A.
Osipova, Ludmila P.
Higham, Thomas F. G.
Ramsey, Christopher Bronk
Hansen, Thomas V. O.
Nielsen, Finn C.
Crawford, Michael H.
Brunak, Soren
Sicheritz-Ponten, Thomas
Villems, Richard
Nielsen, Rasmus
Krogh, Anders
Wang, Jun
Willerslev, Eske
Title Ancient human genome sequence of an extinct Palaeo-Eskimo
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
Publication date 2010-02-11
Sub-type Article (original research)
DOI 10.1038/nature08835
Volume 463
Issue 7282
Start page 757
End page 762
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract We report here the genome sequence of an ancient human. Obtained from 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20Ã-, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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