Two-step source tracing strategy of yersinia pestis and its historical epidemiology in a specific region

Yan, Yanfeng, Wang, Hu, Li, Dongfang, Yang, Xianwei, Wang, Zuyun, Qi, Zhizhen, Zhang, Qingwen, Cui, Baizhong, Guo, Zhaobiao, Yu, Chang, Wang, Jun, Wang, Jian, Liu, Guangming, Song, Yajun, Li, Yingrui, Cui, Yujun and Yang, Ruifu (2014) Two-step source tracing strategy of yersinia pestis and its historical epidemiology in a specific region. PLoS ONE, 9 1: . doi:10.1371/journal.pone.0085374


Author Yan, Yanfeng
Wang, Hu
Li, Dongfang
Yang, Xianwei
Wang, Zuyun
Qi, Zhizhen
Zhang, Qingwen
Cui, Baizhong
Guo, Zhaobiao
Yu, Chang
Wang, Jun
Wang, Jian
Liu, Guangming
Song, Yajun
Li, Yingrui
Cui, Yujun
Yang, Ruifu
Title Two-step source tracing strategy of yersinia pestis and its historical epidemiology in a specific region
Journal name PLoS ONE   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-01-09
Year available 2014
Sub-type Article (original research)
DOI 10.1371/journal.pone.0085374
Open Access Status DOI
Volume 9
Issue 1
Total pages 7
Place of publication San Francisco, United States
Publisher Public Library of Science
Language eng
Abstract Source tracing of pathogens is critical for the control and prevention of infectious diseases. Genome sequencing by high throughput technologies is currently feasible and popular, leading to the burst of deciphered bacterial genome sequences. Utilizing the flooding genomic data for source tracing of pathogens in outbreaks is promising, and challenging as well. Here, we employed Yersinia pestis genomes from a plague outbreak at Xinghai county of China in 2009 as an example, to develop a simple two-step strategy for rapid source tracing of the outbreak. The first step was to define the phylogenetic position of the outbreak strains in a whole species tree, and the next step was to provide a detailed relationship across the outbreak strains and their suspected relatives. Through this strategy, we observed that the Xinghai plague outbreak was caused by Y. pestis that circulated in the local plague focus, where the majority of historical plague epidemics in the Qinghai-Tibet Plateau may originate from. The analytical strategy developed here will be of great help in fighting against the outbreaks of emerging infectious diseases, by pinpointing the source of pathogens rapidly with genomic epidemiological data and microbial forensics information. Copyright:
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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