Mucins and mucus

McGuckin, Michael A., Thornton, David J. and Whitsett, Jeffrey A. (2015). Mucins and mucus. In Jiri Mestecky, Warren Strober, Michael W. Russell, Brian L. Kelsall, Hilde Cheroutre and Bart N. Lambrecht (Ed.), Mucosal immunology: fourth edition Fourth ed. (pp. 231-250) Kidlington, Oxford, United Kingdom: Elsevier. doi:10.1016/B978-0-12-415847-4.00014-8

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Author McGuckin, Michael A.
Thornton, David J.
Whitsett, Jeffrey A.
Title of chapter Mucins and mucus
Title of book Mucosal immunology: fourth edition
Place of Publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Publication Year 2015
Sub-type Research book chapter (original research)
DOI 10.1016/B978-0-12-415847-4.00014-8
Open Access Status Not Open Access
Series Mucosal Immunology
Edition Fourth
ISBN 9780124159754
9780124158474
9780123972033
Editor Jiri Mestecky
Warren Strober
Michael W. Russell
Brian L. Kelsall
Hilde Cheroutre
Bart N. Lambrecht
Volume number 1.A
Chapter number 14
Start page 231
End page 250
Total pages 20
Total chapters 117
Collection year 2016
Language eng
Abstract/Summary Mucosal surfaces are exposed to the external environment and pathogens and are therefore protected by a secreted layer of mucus rich in mucin glycoproteins, which are the main components of mucus. Mucus provides physical protection and hydration, excludes pathogens, and is a reservoir for antimicrobial molecules. Underlying mucus further protection is provided by epithelial cell surface mucins, which limit microbial adherence and regulate growth and apoptosis. Differentiation of the cells that produce mucins, and expression of mucins and proteins involved in mucin biosynthesis, is regulated by innate and adaptive immunity. Experimental deficiencies in mucins lead to infectious and inflammatory diseases, and mucin gene polymorphisms are associated with disease. Many chronic mucosal inflammatory diseases are characterized by mucus hypersecretion driven by immune and microbial factors, which contributes to pathology and is a target for therapy. In this chapter we describe the nature of this mucosal barrier, its regulation and function, and its involvement in human disease, with particular emphasis on the mucin component of the barrier.
Keyword Goblet cell
Innate immunity
Mucin
Mucosal inflammation
Mucus
Pathogen
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Book Chapter
Collections: Mater Research Institute-UQ (MRI-UQ)
Non HERDC
 
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