Taming the TCR: antigen-specific immunotherapeutic agents for autoimmune diseases

Sauer, Evan L., Cloake, Nancy C. and Greer, Judith M. (2015) Taming the TCR: antigen-specific immunotherapeutic agents for autoimmune diseases. International Reviews of Immunology, 34 6: 460-485. doi:10.3109/08830185.2015.1027822


Author Sauer, Evan L.
Cloake, Nancy C.
Greer, Judith M.
Title Taming the TCR: antigen-specific immunotherapeutic agents for autoimmune diseases
Journal name International Reviews of Immunology   Check publisher's open access policy
ISSN 1563-5244
0883-0185
Publication date 2015-05-13
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3109/08830185.2015.1027822
Open Access Status Not Open Access
Volume 34
Issue 6
Start page 460
End page 485
Total pages 26
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2016
Language eng
Abstract Current treatments for autoimmune diseases are typically non-specific anti-inflammatory agents that affect not only the autoreactive cells but also the parts of the immune system that are required to maintain health. There is a need for the development of antigen-specific therapeutic agents that can effectively prevent the autoimmune attack while leaving the rest of the immune system functioning as normal. The simplest way to achieve this is using the autoantigen itself as a tolerizing agent; however, there is some risk involved with administering a potentially pathogenic antigen. In this review, we focus instead on the development and use of modified T cell receptor (TCR) ligands, in which the peptide ligand is modified to change the response by the T cell from a disease inducing to a protective response, and still retain the antigen-specificity necessary to target the autoreactive T cells. We review the use of modified TCR ligands as therapeutic agents in animal models of autoimmunity and in human autoimmune disease, and finally consider how they need to be improved in order to use them effectively in patients with autoimmune disease.
Keyword Antigen-specific
Autoimmune disease
CD4+ T cell
MHC
T cell receptor
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
School of Medicine Publications
 
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