Mesoporous materials modified by aptamers and hydrophobic groups assist ultra-sensitive insulin detection in serum

Lei, Chang, Xu, Chun, Noonan, Owen, Meka, Anand Kumar, Zhang, Long, Nouwens, Amanda and Yu, Chengzhong (2015) Mesoporous materials modified by aptamers and hydrophobic groups assist ultra-sensitive insulin detection in serum. Chemical Communications, 51 71: 13642-13645. doi:10.1039/c5cc04458h


 
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Author Lei, Chang
Xu, Chun
Noonan, Owen
Meka, Anand Kumar
Zhang, Long
Nouwens, Amanda
Yu, Chengzhong
Title Mesoporous materials modified by aptamers and hydrophobic groups assist ultra-sensitive insulin detection in serum
Journal name Chemical Communications   Check publisher's open access policy
ISSN 1364-548X
1359-7345
Publication date 2015-07-17
Year available 2015
Sub-type Article (original research)
DOI 10.1039/c5cc04458h
Open Access Status Not Open Access
Volume 51
Issue 71
Start page 13642
End page 13645
Total pages 4
Place of publication Cambridge, United Kingdom
Publisher R S C Publications
Collection year 2016
Language eng
Formatted abstract
A novel mesoporous material modified with both insulin-binding-aptamers and hydrophobic methyl groups is synthesized. With rationally designed pore structures and surface chemistry, this material is applied in sample pre-treatment for ELISA, and enables the quantification (0.25–5 pg ml−1) of insulin in serum, 30-fold enhancement of the limit-of-detection compared to the commercial ELISA kit.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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