A community-based approach to new antibiotic discovery

Cooper, Matthew A (2015) A community-based approach to new antibiotic discovery. Nature Reviews Drug Discovery, 14 9: 587-588. doi:10.1038/nrd4706

Author Cooper, Matthew A
Title A community-based approach to new antibiotic discovery
Journal name Nature Reviews Drug Discovery   Check publisher's open access policy
ISSN 1474-1784
Publication date 2015-08-07
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrd4706
Open Access Status Not Open Access
Volume 14
Issue 9
Start page 587
End page 588
Total pages 2
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2016
Language eng
Formatted abstract
The Community for Open Antimicrobial Drug Discovery aims to tap into the potential of the millions of compounds distributed around laboratories globally to be a source of new antibiotic leads by offering free screening for antimicrobial properties, with no strings attached.

There has been much written on the 'superbug crisis' over the past decade. Commonly cited causes include the over-use of antibiotics in humans and animals and the exit of many companies from antibacterial drug research and development (R&D) owing to the challenging market economics. However, there is another important cause — it is simply getting more and more difficult to find new antibacterial drugs. Most of the current arsenal of antibacterial drugs originated from screening of natural products in the 1950s–1970s. However, the 'low-hanging fruit' from this strategy appears to have been exhausted, and one alternative — target-based screening using knowledge of bacterial genomics — has failed to replenish the drug pipeline. Consequently, there has been a revival in interest in establishing antimicrobial screening platforms to interrogate previously untapped sources of chemical diversity.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
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