Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens

Koning, Frits, Thomas, Ranjeny, Rossjohn, Jamie and Toes, Rene E. (2015) Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens. Nature Reviews Rheumatology, 11 8: 450-461. doi:10.1038/nrrheum.2015.59


Author Koning, Frits
Thomas, Ranjeny
Rossjohn, Jamie
Toes, Rene E.
Title Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens
Journal name Nature Reviews Rheumatology   Check publisher's open access policy
ISSN 1759-4804
1759-4790
Publication date 2015-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrrheum.2015.59
Open Access Status Not yet assessed
Volume 11
Issue 8
Start page 450
End page 461
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2016
Language eng
Abstract Rheumatoid arthritis (RA) and coeliac disease are inflammatory diseases that both have a strong association with class II HLAs: individuals carrying HLA-DQ2.5 and/or HLA-DQ8 alleles have an increased risk of developing coeliac disease, whereas those carrying HLA-DR shared epitope alleles exhibit an increased risk of developing RA. Although the molecular basis of the association with specific HLA molecules in RA remains poorly defined, an immune response against post-translationally modified protein antigens is a hallmark of each disease. In RA, understanding of the pathogenetic role of B-cell responses to citrullinated antigens, including vimentin, fibrinogen and α-enolase, is rapidly growing. Moreover, insight into the role of HLAs in the pathogenesis of coeliac disease has been considerably advanced by the identification of T-cell responses to deamidated gluten antigens presented in conjunction with predisposing HLA-DQ2.5 molecules. This article briefly reviews these advances and draws parallels between the immune mechanisms leading to RA and coeliac disease, which point to a crucial role for T-cell–B-cell cooperation in the development of full-blown disease. Finally, the ways in which these novel insights are being exploited therapeutically to re-establish tolerance in patients with RA and coeliac disease are described.
Keyword Rheumatoid arthritis (RA)
Coeliac disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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