Risk of cardiovascular disease in HIV-positive Queensland men receiving combined antiretroviral therapy

Furuya-Kanamori, Luis, Kelly, Mark D. and Mckenzie, Samantha J. (2015) Risk of cardiovascular disease in HIV-positive Queensland men receiving combined antiretroviral therapy. Sexual Health, 12 4: 348-352. doi:10.1071/SH14062


Author Furuya-Kanamori, Luis
Kelly, Mark D.
Mckenzie, Samantha J.
Title Risk of cardiovascular disease in HIV-positive Queensland men receiving combined antiretroviral therapy
Journal name Sexual Health   Check publisher's open access policy
ISSN 1449-8987
1448-5028
Publication date 2015-06-01
Sub-type Article (original research)
DOI 10.1071/SH14062
Open Access Status Not yet assessed
Volume 12
Issue 4
Start page 348
End page 352
Total pages 5
Place of publication Collingwood, VIC, Australia
Publisher CSIRO
Collection year 2016
Language eng
Formatted abstract
Background:  Cardiovascular disease (CVD) is a major cause of death among HIV-positive individuals receiving combination antiretroviral therapy (cART). The risk of CVD is estimated using a variety of risk calculations, however, currently there is no specific CVD risk calculator endorsed for Australians receiving cART.

Methods:  A retrospective study of 210 Queensland men older than 35 years with cART-treated HIV was conducted to estimate the prevalence of CVD and the risk of a cardiovascular event occurring within 5 years. The weighted Cohen’s kappa coefficient was used to estimate the agreement between the Australian Absolute CVD Risk Calculator and the Data Collection on Adverse Effects of Anti-HIV Drugs Study (D:A:D) 5-year Estimated CVD Risk Equation.

Results:  The prevalence of CVD was 31.9%. Hypertensive disease was the most prevalent CVD (25.2%). Queensland men with cART-treated HIV were at moderate risk (5%) of a cardiovascular event in the next 5 years. There was a substantial agreement (κ = 0.63) between the Australian Absolute CVD Risk Calculator and the D:A:D 5-year Estimated CVD Risk Equation.

Conclusions:  Queensland men with cART-treated HIV are experiencing high prevalence of CVD and are at moderate risk of a CVD event in the next 5 years. Primary care guidelines should emphasise CVD prevention as a keystone for the treatment of people living with HIV.
Keyword Cardiovascular disease (CVD)
HIV
Queensland, Australia
Combination antiretroviral therapy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Public Health Publications
 
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