Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

Neller, Michelle A., Ladell, Kristin, McLaren, James E., Matthews, Katherine K., Gostick, Emma, Pentier, Johanne M., Dolton, Garry, Schauenburg, Andrea J. A., Koning, Dan, Fontaine Costa, Ana Isabel C. A., Watkins, Thomas S., Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly, Clement, Mathew, Wooldridge, Linda, Cole, David K., Van Baarle, Debbie, Sewell, Andrew K., Burrows, Scott R., Price, David A. and Miles, John J. (2015) Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology, 93 7: 625-633. doi:10.1038/icb.2015.17


Author Neller, Michelle A.
Ladell, Kristin
McLaren, James E.
Matthews, Katherine K.
Gostick, Emma
Pentier, Johanne M.
Dolton, Garry
Schauenburg, Andrea J. A.
Koning, Dan
Fontaine Costa, Ana Isabel C. A.
Watkins, Thomas S.
Venturi, Vanessa
Smith, Corey
Khanna, Rajiv
Miners, Kelly
Clement, Mathew
Wooldridge, Linda
Cole, David K.
Van Baarle, Debbie
Sewell, Andrew K.
Burrows, Scott R.
Price, David A.
Miles, John J.
Title Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics
Formatted title
Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics
Journal name Immunology and Cell Biology   Check publisher's open access policy
ISSN 1440-1711
0818-9641
Publication date 2015-08-01
Sub-type Article (original research)
DOI 10.1038/icb.2015.17
Open Access Status DOI
Volume 93
Issue 7
Start page 625
End page 633
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2016
Language eng
Formatted abstract
Basic parameters of the naive antigen (Ag)-specific T-cell repertoire in humans remain poorly defined. Systematic characterization of this ‘ground state’ immunity in comparison with memory will allow a better understanding of clonal selection during immune challenge. Here, we used high-definition cell isolation from umbilical cord blood samples to establish the baseline frequency, phenotype and T-cell antigen receptor (TCR) repertoire of CD8+ T-cell precursor populations specific for a range of viral and self-derived Ags. Across the board, these precursor populations were phenotypically naive and occurred with hierarchical frequencies clustered by Ag specificity. The corresponding patterns of TCR architecture were highly ordered and displayed partial overlap with adult memory, indicating biased structuring of the T-cell repertoire during Ag-driven selection. Collectively, these results provide new insights into the complex nature and dynamics of the naive T-cell compartment.
Keyword CD8+
T-cell precursors
Antigen-driven selection dynamics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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