Incorporating bioavailability into toxicity assessment of Cu-Ni, Cu-Cd, and Ni-Cd mixtures with the extended biotic ligand model and the WHAM-Ftox approach

Qiu, Hao, Vijver, Martina G., He, Erkai, Liu, Yang, Wang, Peng, Xia, Bing, Smolders, Erik, Versieren, Liske and Peijnenburg, Willie J. G. M. (2015) Incorporating bioavailability into toxicity assessment of Cu-Ni, Cu-Cd, and Ni-Cd mixtures with the extended biotic ligand model and the WHAM-Ftox approach. Environmental Science and Pollution Research, 22 23: 19213-19223. doi:10.1007/s11356-015-5130-2


Author Qiu, Hao
Vijver, Martina G.
He, Erkai
Liu, Yang
Wang, Peng
Xia, Bing
Smolders, Erik
Versieren, Liske
Peijnenburg, Willie J. G. M.
Title Incorporating bioavailability into toxicity assessment of Cu-Ni, Cu-Cd, and Ni-Cd mixtures with the extended biotic ligand model and the WHAM-Ftox approach
Formatted title
Incorporating bioavailability into toxicity assessment of Cu-Ni, Cu-Cd, and Ni-Cd mixtures with the extended biotic ligand model and the WHAM-Ftox approach
Journal name Environmental Science and Pollution Research   Check publisher's open access policy
ISSN 1614-7499
0944-1344
Publication date 2015-08-08
Sub-type Article (original research)
DOI 10.1007/s11356-015-5130-2
Open Access Status Not Open Access
Volume 22
Issue 23
Start page 19213
End page 19223
Total pages 11
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2016
Language eng
Formatted abstract
There are only a limited number of studies that have developed appropriate models which incorporate bioavailability to estimate mixture toxicity. Here, we explored the applicability of the extended biotic ligand model (BLM) and the WHAM-F tox approach for predicting and interpreting mixture toxicity, with the assumption that interactions between metal ions obey the BLM theory. Seedlings of lettuce Lactuca sativa were exposed to metal mixtures (Cu-Ni, Cu-Cd, and Ni-Cd) contained in hydroponic solutions for 4 days. Inhibition to root elongation was the endpoint used to quantify the toxic response. Assuming that metal ions compete with each other for binding at a single biotic ligand, the extended BLM succeeded in predicting toxicity of three mixtures to lettuce, with more than 82 % of toxicity variation explained. There were no significant differences in the values of fmix50 (i.e., the overall amounts of metal ions bound to the biotic ligand inducing 50 % effect) for the three mixture combinations, showing the possibility of extrapolating these values to other binary metal combinations. The WHAM-Ftox approach showed a similar level of precision in estimating mixture toxicity while requiring fewer parameters than the BLM-f mix model. External validation of the WHAM-Ftox approach using literature data showed its applicability for other species and other mixtures. The WHAM-Ftox model is suitable for delineating mixture effects where the extended BLM also applies. Therefore, in case of lower data availability, we recommend the lower parameterized WHAM-Ftox as an effective approach to incorporate bioavailability in quantifying mixture toxicity.
Keyword Bioavailability
Biotic ligand model
Metals
Mixture interactions
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Agriculture and Food Sciences
Official 2016 Collection
 
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