Ventromedial prefrontal cortex drives hippocampal theta oscillations induced by mismatch computations

Garrido, Marta I., Barnes, Gareth R., Kumaran, Dharshan, Maguire, Eleanor A. and Dolan, Raymond J. (2015) Ventromedial prefrontal cortex drives hippocampal theta oscillations induced by mismatch computations. NeuroImage, 120 362-370. doi:10.1016/j.neuroimage.2015.07.016


Author Garrido, Marta I.
Barnes, Gareth R.
Kumaran, Dharshan
Maguire, Eleanor A.
Dolan, Raymond J.
Title Ventromedial prefrontal cortex drives hippocampal theta oscillations induced by mismatch computations
Journal name NeuroImage   Check publisher's open access policy
ISSN 1095-9572
1053-8119
Publication date 2015-10-05
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2015.07.016
Open Access Status DOI
Volume 120
Start page 362
End page 370
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Abstract Detecting environmental change is fundamental for adaptive behavior in an uncertain world. Previous work indicates the hippocampus supports the generation of novelty signals via implementation of a match–mismatch detector that signals when an incoming sensory input violates expectations based on past experience. While existing work has emphasized the particular contribution of the hippocampus, here we ask which other brain structures also contribute to match–mismatch detection. Furthermore, we leverage the fine-grained temporal resolution of magnetoencephalography (MEG) to investigate whether mismatch computations are spectrally confined to the theta range, based on the prominence of this range of oscillations in models of hippocampal function. By recording MEG activity while human subjects perform a task that incorporates conditions of match–mismatch novelty we show that mismatch signals are confined to the theta band and are expressed in both the hippocampus and ventromedial prefrontal cortex (vmPFC). Effective connectivity analyses (dynamic causal modeling) show that the hippocampus and vmPFC work as a functional circuit during mismatch detection. Surprisingly, our results suggest that the vmPFC drives the hippocampus during the generation and processing of mismatch signals. Our findings provide new evidence that the hippocampal–vmPFC circuit is engaged during novelty processing, which has implications for emerging theories regarding the role of vmPFC in memory.
Keyword Connectivity
Hippocampus
MEG
Mismatch
Novelty
Prediction
Theta entrainment
Uncertainty
Ventromedial prefrontal cortex
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
Centre for Advanced Imaging Publications
 
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