Crosslinking to enhance colloidal stability and redispersity of layered double hydroxide nanoparticles

Zuo, Huali, Gu, Zi, Cooper, Helen and Xu, Zhi Ping (2015) Crosslinking to enhance colloidal stability and redispersity of layered double hydroxide nanoparticles. Journal of Colloid and Interface Science, 459 10-16. doi:10.1016/j.jcis.2015.07.063

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Zuo, Huali
Gu, Zi
Cooper, Helen
Xu, Zhi Ping
Title Crosslinking to enhance colloidal stability and redispersity of layered double hydroxide nanoparticles
Journal name Journal of Colloid and Interface Science   Check publisher's open access policy
ISSN 1095-7103
0021-9797
Publication date 2015-12-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.jcis.2015.07.063
Open Access Status File (Author Post-print)
Volume 459
Start page 10
End page 16
Total pages 7
Place of publication Maryland Heights, MO United States
Publisher Academic Press
Collection year 2016
Language eng
Abstract This article introduces a strategy for stabilizing and redispersing layered double hydroxide (LDH) nanoparticles by crosslinking bovine serum albumin (BSA) coated onto the surface. The strategy involves optimization of the amount of the crosslinking agent glutaraldehyde (GTA) to achieve minimal aggregation and ready redispersion. LDH nanoparticles were prepared by co-precipitation and hydrothermal treatment, with subsequent BSA coating at the BSA/LDH mass ratio of 5:2. BSA coated onto LDH nanoparticles was crosslinked with different amounts of GTA. Aggregation studies using dilution assays, dynamic light scattering, and zeta potential analysis indicated that severe aggregation at lower LDH nanoparticle concentrations can be prevented by proper crosslinking of BSA with GTA. The GTA-crosslinked BSA-coated nanoparticles showed excellent redispersity compared to the non-crosslinked nanoparticles. In vitro cytotoxicity and cell uptake were found to be minimally affected by GTA-crosslinking. The new strategy therefore provides a much more effective method for the prevention of LDH nanoparticle aggregation and improved LDH nanoparticle redispersion for use in a wide variety of bio-applications in vitro and in vivo.
Keyword Layered double hydroxide (LDH)
Bovine serum albumin (BSA)
Stabilisation
Nanoparticle aggregation
Crosslinking
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 25 Aug 2015, 00:11:51 EST by System User on behalf of Aust Institute for Bioengineering & Nanotechnology