Mitii™ ABI: study protocol of a randomised controlled trial of a web-based multi-modal training program for children and adolescents with an Acquired Brain Injury (ABI)

Boyd, Roslyn N., Baque, Emmah, Piovesana, Adina, Ross, Stephanie, Ziviani, Jenny, Sakzewski, Leanne, Barber, Lee, Lloyd, Owen, McKinlay, Lynne, Whittingham, Koa, Smith, Anthony C., Rose, Stephen, Fiori, Simona, Cunnington, Ross, Ware, Robert, Lewis, Melinda, Comans, Tracy A. and Scuffham, Paul A. (2015) Mitii™ ABI: study protocol of a randomised controlled trial of a web-based multi-modal training program for children and adolescents with an Acquired Brain Injury (ABI). BMC Neurology, 15 140: . doi:10.1186/s12883-015-0381-6


Author Boyd, Roslyn N.
Baque, Emmah
Piovesana, Adina
Ross, Stephanie
Ziviani, Jenny
Sakzewski, Leanne
Barber, Lee
Lloyd, Owen
McKinlay, Lynne
Whittingham, Koa
Smith, Anthony C.
Rose, Stephen
Fiori, Simona
Cunnington, Ross
Ware, Robert
Lewis, Melinda
Comans, Tracy A.
Scuffham, Paul A.
Title Mitii™ ABI: study protocol of a randomised controlled trial of a web-based multi-modal training program for children and adolescents with an Acquired Brain Injury (ABI)
Journal name BMC Neurology   Check publisher's open access policy
ISSN 1471-2377
Publication date 2015-08-19
Sub-type Article (original research)
DOI 10.1186/s12883-015-0381-6
Open Access Status DOI
Volume 15
Issue 140
Total pages 29
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2016
Language eng
Formatted abstract
Background
Acquired brain injury (ABI) refers to multiple disabilities arising from damage to the brain acquired after birth. Children with an ABI may experience physical, cognitive, social and emotional-behavioural impairments which can impact their ability to participate in activities of daily living (ADL). Recent developments in technology have led to the emergence of internet-delivered therapy programs. “Move it to improve it” (Mitii™) is a web-based multi-modal therapy that comprises upper limb (UL) and cognitive training within the context of meaningful physical activity. The proposed study aims to compare the efficacy of Mitii™ to usual care to improve ADL motor and processing skills, gross motor capacity, UL and executive functioning in a randomised waitlist controlled trial.

Methods/Design
Sixty independently ambulant children (30 in each group) at least 12 months post ABI will be recruited to participate in this trial. Children will be matched in pairs at baseline and randomly allocated to receive either 20 weeks of Mitii™ training (30 min per day, six days a week, with a potential total dose of 60 h) immediately, or be waitlisted for 20 weeks. Outcomes will be assessed at baseline, immediately post-intervention and at 20 weeks post-intervention. The primary outcomes will be the Assessment of Motor and Process Skills and 30 s repetition maximum of functional strength exercises (sit-to-stand, step-ups and half kneel to stand). Measures of body structure and functions, activity, participation and quality of life will assess the efficacy of Mitii™ across all domains of the International Classification of Functioning, Disability and Health framework. A subset of children will undertake three tesla (3T) magnetic resonance imaging scans to evaluate functional neurovascular changes, structural imaging, diffusion imaging and resting state functional connectivity before and after intervention.

Discussion
Mitii™ provides an alternative approach to deliver intensive therapy for children with an ABI in the convenience of the home environment. If Mitii™ is found to be effective, it may offer an accessible and inexpensive intervention option to increase therapy dose.
Keyword Acquired Brain Injury
Children
Physical Activity
Virtual Reality
Motor Processing
Protocol
Executive function
Randomised Controlled Trial
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Thu, 20 Aug 2015, 19:34:37 EST by Ms Leanne Sakzewski on behalf of School of Health & Rehabilitation Sciences