Effects of atorvastatin on oxidative stress in chronic kidney disease

Fassett, Robert G., Robertson, Iain K., Ball, Madeleine J., Geraghty, Dominic P. and Coombes, Jeff S. (2015) Effects of atorvastatin on oxidative stress in chronic kidney disease. Nephrology, 20 10: 697-705. doi:10.1111/nep.12502

Author Fassett, Robert G.
Robertson, Iain K.
Ball, Madeleine J.
Geraghty, Dominic P.
Coombes, Jeff S.
Title Effects of atorvastatin on oxidative stress in chronic kidney disease
Journal name Nephrology   Check publisher's open access policy
ISSN 1320-5358
Publication date 2015-10
Sub-type Article (original research)
DOI 10.1111/nep.12502
Open Access Status Not Open Access
Volume 20
Issue 10
Start page 697
End page 705
Total pages 31
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2016
Language eng
Formatted abstract
Aim: Statins have pleiotropic effects that include attenuation of oxidative stress that may be relevant for CKD patients. We investigated the effect of long term atorvastatin therapy on oxidative stress biomarkers in CKD patients.

Methods: This was a pre-specified secondary analysis of data from a randomized, double-blind, placebo-controlled trial (Lipid lowering and Onset of Renal Disease, LORD) in CKD patients. Participants received 10 mg/day atorvastatin (n=47) or placebo (n=39) for three-years. Plasma measures (total F2-isoprostanes, malondialdehyde. protein carbonyls, uric acid, glutathione peroxidase (GPx) activity and total antioxidant capacity (TAC)) were performed at baseline and at three years. Age and sex matched participants (n=34) with normal kidney function were controls.

Results: CKD patients had significantly (P<0.05) increased F2-isoprostanes and uric acid, and decreased GPx activity compared to controls. When comparing the treatment (atorvastatin, A vs placebo, P) change from baseline to three years, there were no significant differences (P>0.05) in the group difference of the change values: (mean(95%CI), F2-isoprostanes=5.3 (-29.2 to 39.8) pg/mL , protein carbonyls=0.03(-0.13 to 0.19) nmol/mg, GPx activity=-0.10(-4.73 to 4.52) (U/L) , uric acid=8.8(-33.9 to 51.6) μmol/L or TAC=-0.03(-0.10 to 0.04) mmol/L . A significant difference (P=0.04) in the change in malondialdehyde between groups; 1.52(0.09 to 2.96) μmol/L, was due to a large decrease in the placebo group.

Conclusion: CKD patients had elevated oxidative stress that was not attenuated by atorvastatin 10mg/day for three-years.
Keyword F2 isoprostanes
Protein Carbonyls
Uuric acid
Glutathione peroxidase
Total antioxidant status
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 19 Aug 2015, 10:01:21 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences