Exercise and Vascular Function in Child Obesity: A Meta-Analysis

Dias, Katrin A, Green, Daniel J, Ingul, Charlotte B, Pavey, Toby G and Coombes, Jeff S (2015) Exercise and Vascular Function in Child Obesity: A Meta-Analysis. Pediatrics, 136 3: 648-659. doi:10.1542/peds.2015-0616

Author Dias, Katrin A
Green, Daniel J
Ingul, Charlotte B
Pavey, Toby G
Coombes, Jeff S
Title Exercise and Vascular Function in Child Obesity: A Meta-Analysis
Journal name Pediatrics   Check publisher's open access policy
ISSN 0031-4005
Publication date 2015
Year available 2015
Sub-type Article (original research)
DOI 10.1542/peds.2015-0616
Open Access Status Not yet assessed
Volume 136
Issue 3
Start page 648
End page 659
Total pages 12
Place of publication Grove Village, United States
Publisher American Academy of Pediatrics
Collection year 2016
Language eng
Formatted abstract
CONTEXT: Conduit artery flow-mediated dilation (FMD) is a noninvasive index of preclinical atherosclerosis in humans. Exercise interventions can improve FMD in both healthy and clinical populations.

OBJECTIVE: This systematic review and meta-analysis aimed to summarize the effect of exercise training on FMD in overweight and obese children and adolescents as well as investigate the role of cardiorespiratory fitness (peak oxygen consumption [VO2peak]) on effects observed.

DATA SOURCES: PubMed, Medline, Embase, and Cinahl databases were searched from the earliest available date to February 2015.

STUDY SELECTION: Studies of children and/or adolescents who were overweight or obese were included.

DATA EXTRACTION: Standardized data extraction forms were used for patient and intervention characteristics, control/comparator groups, and key outcomes. Procedural quality of the studies was assessed using a modified version of the Physiotherapy Evidence Base Database scale.

RESULTS: A meta-analysis involving 219 participants compared the mean difference of pre- versus postintervention vascular function (FMD) and VO2peak between an exercise training intervention and a control condition. There was a significantly greater improvement in FMD (mean difference 1.54%, P < .05) and VO2peak (mean difference 3.64 mL/kg/min, P < .05) after exercise training compared with controls.

LIMITATIONS: Given the diversity of exercise prescriptions, participant characteristics, and FMD measurement protocols, varying FMD effect size was noted between trials.

CONCLUSIONS: Exercise training improves vascular function in overweight and obese children, as indicated by enhanced FMD. Further research is required to establish the optimum exercise program for maintenance of healthy vascular function in this at-risk pediatric population.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Human Movement and Nutrition Sciences Publications
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Created: Tue, 18 Aug 2015, 17:05:53 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences