The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens.

Djoko, Karrera Y, Ong, Cheryl-lynn Y, Walker, Mark J and McEwan, Alastair G (2015) The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens.. Journal of Biological Chemistry, 290 31: 18954-18961. doi:10.1074/jbc.R115.647099

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Author Djoko, Karrera Y
Ong, Cheryl-lynn Y
Walker, Mark J
McEwan, Alastair G
Title The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens.
Journal name Journal of Biological Chemistry   Check publisher's open access policy
ISSN 0021-9258
1083-351X
Publication date 2015-07-31
Year available 2015
Sub-type Article (original research)
DOI 10.1074/jbc.R115.647099
Open Access Status File (Publisher version)
Volume 290
Issue 31
Start page 18954
End page 18961
Total pages 8
Place of publication Bethesda, United States
Publisher American Society for Biochemistry and Molecular Biology
Collection year 2016
Language eng
Abstract Zinc (Zn) and copper (Cu) are essential for optimal innate immune function, and nutritional deficiency in either metal leads to increased susceptibility to bacterial infection. Recently, the decreased survival of bacterial pathogens with impaired Cu and/or Zn detoxification systems in phagocytes and animal models of infection has been reported. Consequently, a model has emerged in which the host utilizes Cu and/or Zn intoxication to reduce the intracellular survival of pathogens. This review describes and assesses the potential role for Cu and Zn intoxication in innate immune function and their direct bactericidal function.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Tue, 18 Aug 2015, 10:18:26 EST by Prycilla Rehm on behalf of School of Chemistry & Molecular Biosciences